Evaluation of cutaneous, oral and intestinal microbiota in patients affected by pemphigus and bullous pemphigoid: A pilot study.
CONCLUSION: Firmicutes phylum and Staphilococcus genus were the most represented in OM and CM swabs of PV and BP microbial populations. Moreover, we argue the quantitative imbalance linked to the decrease of Bacteriodetes in the oral cavity of PV patients might be associated to disease typical fetor. To shed light on this peculiar feature further studies are still required. PMID: 31705881 [PubMed - as supplied by publisher]
Publication date: Available online 14 September 2020Source: Autoimmunity ReviewsAuthor(s): Hui Fang, Qingyang Li, Gang Wang
CONCLUSIONS: This retrospective study summarizes the patient characteristics, comorbidities, treatment choices and side effects in our 16 years of clinical practice. PMID: 32892539 [PubMed - as supplied by publisher]
Desquamative gingivitis is a generic condition with gingival scaling that can be a manifestation of autoimmune diseases such as lichen planus, pemphigus, and pemphigoid, etc. Diagnosis is based on biopsy of the lesions, hematoxylin and eosin staining (HE), and direct immunofluorescence, and the treatment of choice is the use of corticosteroids. A 59-year-old white female presented with areas of intense erythema and extensive ulcerations spread throughout the gingivae on both arches and on the hard palate, which stopped her from adequately feeding due to pain and bleeding.
Objective: To compare clinical manifestations and outcome of applied treatments of pemphigus vulgaris (PV) and mucous membrane pemphigoid (MMP). Study Design: Retrospective cohort study through the analysis of records of a stomatology service for 33 years. Demographic data, comorbidities, medications, symptoms, clinical, and histopathological description of the lesions, diagnostic hypothesis, final diagnosis, extraoral manifestations, treatment, and follow-up were collected. Descriptive analysis was performed.
Conclusions: Abnormal vitamin D status are more common in AIBD patients than that in general population. Therefore, regular monitoring of vitamin D levels and vitamin D supplementation should be considered as part of the management strategy for AIBD. PMID: 32799714 [PubMed - as supplied by publisher]
The cells of myeloid origin, mature granulocytes and monocytes, are generally acknowledged with innate functions in pathogen clearance, however they possess great capacity to modulate T cell immunity (Chen and Flies 2013). Alternatively, exposure to weak and sustained proinflammatory mediators from chronic pathological conditions as such observed in cancer and autoimmunity may create an imbalance in favor of immature myeloid cells (Veglia et al. 2018) (Zhao et al. 2016). Accordingly, immature myeloid cells ’ egress from bone marrow are increased and these cells accumulate in circulation, secondary immune organs and s...
The objective of the study was to determine whether atopic dermatitis (AD), psoriasis, pemphigus, pemphigoid and/or hidradenitis is associated with VTE in US adults. Data were analyzed from the 2002 –2012 Nationwide Inpatient Sample, a representative cohort of US hospitalizations (N = 72,512,581 adults, including 1,389,292 with VTE). In multivariable logistic regression models including age, sex, insurance, household income and race/ethnicity, hospitalization for AD (adjusted odds ratio [95% confidence intervals] 1.22 [1.17–1.27]), pemphigus (1.96 [1.68–2.28]) and pemp higoid (1.64 [1.47&nda...
Conclusion: Rituximab is safe and effective in childhood/juvenile patients with AIBDs. Furthermore, RTX can be used as first-line treatment in pediatric patients with pemphigus. PMID: 32589481 [PubMed - as supplied by publisher]
Autoimmune blistering diseases (AIBDs), mainly including epidermolysis bullosa acquisita (EBA), pemphigus Vulgaris (PV) and bullous pemphigoid (BP), are a large class of autoimmune diseases presenting the blistering eruptions on the skin and mucosa membrane. Circulating autoantibodies play a critical role in the pathogenesis, antibody-specific B cells and CD4+T cells involved as well. While vitiligo, a common pigmentation disorder, is mostly considered as CD8+T cell-mediated, with multiple melanocyte-derived autoantibodies also detectable in part of the patients, although its pathogenicity remains undetermined.
Autoimmune blistering diseases (AIBDs) are a group of rare acquired blistering skin diseases, which are divided into five major subtypes based on the clinical appearance and pathology: pemphigus diseases, bullous pemphigoid (BP), epidermolysis bullosa acquisita (EBA), dermatitis herpetiformis (DH) and Linear IgA bullous dermatosis (LigA). Current understanding has been greatly increased by genetic investigations mainly focus on the HLA in various populations. We have conducted the HLA association studies on different subtypes of AIBDs in Chinese population by using Next-generation (NGS) based HLA typing methods.