Swimming reduces fatty acids-associated hypothalamic damage in mice

Publication date: Available online 11 November 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Pedro Augusto Silva Nogueira, Miriam Pimenta Pereira, Jeferson José Gomes Soares, Juliana de Assis Silva Gomes, Daniele Lisboa Ribeiro, Daniela Soares Razolli, Licio Augusto Velloso, Morun Bernardino Neto, Renata Graciele ZanonAbstractThe arcuate and the paraventricular and lateral hypothalamic nuclei, related to hunger and satiety control, are generally compromised by excess fatty acids. In this situation, fatty acids cause inflammation via TLR4 (toll like receptor 4) and the nuclei become less responsive to the hormones leptin and insulin, contributing to the development of obesity. In this work, these nuclei were analyzed in animals fed with high-fat diet and submitted to swimming without and with load for two months. For this, frontal sections of the hypothalamus were immunolabelled with GFAP (glial fibrillary acidic protein), synaptophysin, IL-6 (interleukin 6) and TLR4. Also, proteins extracted from the hypothalamus were analyzed using Western blotting (GFAP and synaptophysin), fluorometric analysis for caspases 3 and 7, and CBA (cytometric bead array) for Th1, Th2, and Th17 profiles. The high-fat diet significantly caused overweight and, in the hypothalamus, decreased synapses and increased astrocytic reactivity. The swimming with load, especially 80% of the maximum load, reduced those consequences. The high-fat diet increased TLR4 in the arcuate nucleus and the...
Source: Journal of Chemical Neuroanatomy - Category: Neuroscience Source Type: research

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Publication date: Available online 14 December 2019Source: Trends in Food Science &TechnologyAuthor(s): Elisangela Aparecida Nazario Franco, Ana Sanches-Silva, Regiane Ribeiro-Santos, Nathália Ramos de MeloAbstractBackgroundFiber intake has been associated with a lower risk of developing various chronic diseases such as metabolic diseases (e.g. obesity, diabetes, dyslipidemia). In this line, psyllium presents a high content of soluble fiber, associated with health benefits.Scope and approachThe aim of this review is to evaluate the scientific evidence of psyllium health benefits. The nutritional properties of ps...
Source: Trends in Food Science and Technology - Category: Food Science Source Type: research
CONCLUSION: Despite differences between adults with SCI and adults with CVD in several demographic and health-related measures, the overall similarity in PARs for SCI and CVD suggests potential benefits from using effective CVD interventions to address SCI. PMID: 31835014 [PubMed - in process]
Source: Public Health Reports - Category: International Medicine & Public Health Tags: Public Health Rep Source Type: research
Publication date: 15 January 2020Source: Life Sciences, Volume 241Author(s): Ekaterina Veniaminova, Margarita Oplatchikova, Lucien Bettendorff, Elena Kotenkova, Alexander Lysko, Ekaterina Vasilevskaya, Allan V. Kalueff, Liliya Fedulova, Aleksei Umriukhin, Klaus-Peter Lesch, Daniel C. Anthony, Tatyana StrekalovaAbstractAimsThe high sugar and lipid content of the Western diet (WD) is associated with metabolic dysfunction, non-alcoholic steatohepatitis, and it is an established risk factor for neuropsychiatric disorders. Our previous studies reported negative effects of the WD on rodent emotionality, impulsivity, and sociabil...
Source: Life Sciences - Category: Biology Source Type: research
ConclusionNo relationship was found between the subgroup of obese adult patients receiving IMV and the mortality variable in the ICU.ResumenObjetivoEvaluar si existe asociación entre obesidad y mortalidad en la Unidad de Cuidados Intensivos (UCI) en pacientes adultos que reciben ventilación mecánica invasiva.DiseñoRevisión sistemática con metaanálisis.ÁmbitoUCI.Fuente de datosSe realizó una búsqueda en las bases de datos MEDLINE, Cochrane Library, CINAHL y Global Health sin restricción de lenguaje, hasta el 21 de febrero del año 2017.Selecc...
Source: Medicina Intensiva - Category: Intensive Care Source Type: research
Conclusions: A screening tool based on heart rate variability and anthropometric parameters was developed to identify subjects with higher probability of suffering or developing cardio metabolic risk factors. PMID: 31829032 [PubMed - as supplied by publisher]
Source: Blood Pressure - Category: Hematology Tags: Blood Press Source Type: research
This study compared the effects of different frequencies of HIIT with those of moderate-intensity continuous training (MICT) on body composition in overweight or obese adults. Methods Fifty-six overweight or obese (body mass index = 26.4 ± 2.9) men between 18 and 30 yr old (age = 22.8 ± 3.1 yr) were randomly assigned to the following groups: no-intervention control (CON; n = 14), MICT performed thrice weekly (MICT×3/wk; n = 9), HIIT performed thrice weekly (HIIT×3/wk; n = 14), HIIT performed twice weekly (HIIT×2/wk; n = 10), and HIIT performed once weekly (HIIT×1/wk; n = 9). Each HI...
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: APPLIED SCIENCES Source Type: research
Introduction Intestinal metabolism and microbiota profiles are impaired in obesity and insulin resistance. Moreover, dysbiotic gut microbiota has been suggested to promote systemic low-grade inflammation and insulin resistance through the release of endotoxins particularly lipopolysaccharides. We have previously shown that exercise training improves intestinal metabolism in healthy men. To understand whether changes in intestinal metabolism interact with gut microbiota and its release of inflammatory markers, we studied the effects of sprint interval (SIT) and moderate-intensity continuous training (MICT) on intestinal m...
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: APPLIED SCIENCES Source Type: research
Purpose Individuals who are obese, and older individuals, exhibit gait alterations that may result, in part, from walking with greater effort relative to their maximum strength capacity. The goal of this study was to investigate obesity-related and age-related differences in relative effort during gait. Methods Four groups of women completed the study, including 10 younger healthy-weight, 10 younger obese, 10 older healthy-weight, and 9 older obese women. The protocol included strength measurements at the hip, knee, and ankle in both flexion and extension, and gait trials under self-selected and constrained (1.5 m&mid...
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: APPLIED SCIENCES Source Type: research
Authors: McLeod GF, Fergusson DM, Horwood LJ, Boden JM, Carter FA Abstract AIMS: The increasing prevalence of overweight and obesity has become a key challenge for New Zealand. The purpose of the present study was to examine childhood risk factors for adult adiposity in a longitudinal birth cohort. METHODS: Data were gathered from the Christchurch Health and Development Study (CHDS), a birth cohort of 1,265 children born in Christchurch in 1977. Associations were examined between socio-demographic background, perinatal factors, infant and child characteristics, family functioning/child maltreatment and adiposit...
Source: New Zealand Medical Journal - Category: General Medicine Tags: N Z Med J Source Type: research
Publication date: Available online 14 December 2019Source: Journal of Minimally Invasive GynecologyAuthor(s): Julia Whitley, Kristin J. Moore, Erin T. Carey, Michelle LouieAbstractStudy ObjectiveTo compare intra-operative and 30-day post-hysterectomy outcomes between patients who had bariatric surgery before hysterectomy and patients with body mass index (BMI)>40 kg/m2 without prior bariatric surgery.DesignA retrospective cohort study.SettingA tertiary-care academic medical center.PatientsPatients with a history of bariatric surgery and patients with body mass index (BMI)>40 kg/m2 and no prior bariatric surgery under...
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
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