High-density lipoproteins from egg yolk's effect on hyperlipidemia in a high-fat-diet obese mouse using lipidomic analysis

Publication date: Available online 12 November 2019Source: Food BioscienceAuthor(s): Zhihui Yu, Ning Wang, Fang Geng, Meihu MaAbstractObesity induced by consuming a high-fat diet (HFD) is a major risk for nonalcoholic fatty liver disease, which has become a worldwide health problem. To study the effects of high-density lipoproteins of egg yolk (EYHDL) on mice with HFD induced obesity, lipidomic analyses using ultra performance liquid chromatography/tandem mass spectrometry (UPLC-MS/MS) was done with serum and liver samples on 60 and 100 days. The results showed that EYHDL significantly alleviated mouse obesity by decreasing adipose tissue accumulation, serum low-density lipoproteins cholesterol, total cholesterol, hepatic triglycerides and development of hepatic steatosis. The EYHDL group was separated from HFD on the orthogonal partial least squares-discriminant analysis score plots, suggesting the beneficial effect of EYHDL on dyslipidemia in obese mice. Volcano plots combined with S-plots showed that the potential biomarkers contributing to these differences were diglycerides, phosphatidylcholines, phosphatidylinositols and lysophosphatidylcholines. On the basis of these biomarkers, glycerophospholipid metabolism is probably the main pathway regulated by EYHDL in obese mice. In summary, EYHDL alleviated hyperlipidemia in obese mice by regulating the phosphatidylcholines and neutral glycerolipids composition, and the lipid biomarkers can be used to better assess the mechani...
Source: Food Bioscience - Category: Food Science Source Type: research

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CONCLUSION: Gender, BMI, and HDL were found to be predictors of steatosis. Male patients with low HDL and high BMI are at greater risk of steatosis and should be carefully examined for the presence of NAFLD. PMID: 31754954 [PubMed - as supplied by publisher]
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Source: Aging - Category: Biomedical Science Authors: Tags: Aging (Albany NY) Source Type: research
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Source: BioFactors - Category: Biochemistry Authors: Tags: RESEARCH COMMUNICATION Source Type: research
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Source: Science Translational Medicine - Category: Biomedical Science Authors: Tags: Research Articles Source Type: research
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Source: Biochemical and Biophysical Research communications - Category: Biochemistry Authors: Tags: Biochem Biophys Res Commun Source Type: research
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Source: Current Vascular Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Vasc Pharmacol Source Type: research
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