In vitro models for investigation of the host-parasite interface - possible applications in acute Chagas Disease.

In vitro models for investigation of the host-parasite interface - possible applications in acute Chagas Disease. Acta Trop. 2019 Nov 07;:105262 Authors: Breyner NM, Hetch M, Nitz N, Rose E, de Carvalho JL Abstract Chagas disease (CD), caused by Trypanosoma cruzi, is the main parasitic disease in the Western Hemisphere, with an increasing number of cases, especially in non-endemic regions. The disease is characterized by cardiomegaly and mega viscera, nevertheless, the clinical outcome is hard to predict, underscoring the need for further research into the pathophysiology of CD. Even though most basic and translational research involving CD is performed using in vivo models, in vitro models arise as an ethical, rapidly evolving, and physiologically relevant alternative for CD research. In the present review, we discuss the most past and recent in vitro cardiac and intestinal models available to study the host-parasite interface in CD, critically analyzing the possibilities and limitations of state-of-the-art alternatives for the CD host-parasite investigation. PMID: 31706861 [PubMed - as supplied by publisher]
Source: Acta Tropica - Category: Infectious Diseases Authors: Tags: Acta Trop Source Type: research