Recurring outbreaks of acute encephalitis syndrome cases in Bihar: A conundrum for experts and health system

Shalini Sunderam, Dewesh KumarIndian Journal of Community Medicine 2019 44(4):403-403
Source: Indian Journal of Community Medicine - Category: International Medicine & Public Health Authors: Source Type: research

Related Links:

Publication date: Available online 6 December 2019Source: Antiviral ResearchAuthor(s): Andrew M. Skidmore, Robert S. Adcock, Colleen B. Jonsson, Jennifer E. Golden, Dong-Hoon ChungAbstractVenezuelan equine encephalitis virus (VEEV) is an alphavirus that is endemic to the Americas. VEEV outbreaks occur periodically and cause encephalitis in both humans and equids. There are currently no therapeutics or vaccines for treatment of VEEV in humans. Our group has previously reported on the development of a benzamidine VEEV inhibitor, ML336, which shows potent antiviral activity in both in vitro and in vivo models of infection. In...
Source: Antiviral Therapy - Category: Virology Source Type: research
Abstract Venezuelan equine encephalitis virus (VEEV) is an alphavirus that is endemic to the Americas. VEEV outbreaks occur periodically and cause encephalitis in both humans and equids. There are currently no therapeutics or vaccines for treatment of VEEV in humans. Our group has previously reported on the development of a benzamidine VEEV inhibitor, ML336, which shows potent antiviral activity in both in vitro and in vivo models of infection. In cell culture experiments, ML336 inhibits viral RNA synthesis when added 2-4 h post-infection, and mutations conferring resistance occur within the viral nonstructural ...
Source: Antiviral Research - Category: Virology Authors: Tags: Antiviral Res Source Type: research
Publication date: Available online 29 November 2019Source: Protein Expression and PurificationAuthor(s): Jae-Won Choi, Hyo-Ji Eom, Hak Yong KimAbstractJapanese encephalitis virus (JEV) is a member of the Flavivirus genus and has recently attracted attention as a high-risk pathogen in the Asia-Pacific region, with up to 30% mortality in the afflicted patients. Recent outbreaks of flavivirus-associated infections around the world have put the focus on non-structural protein 1 (NS1) as a candidate for diagnostic and vaccine researches on flaviviruses. Although the JEV NS1 protein has been expressed in eukaryotic cells, attemp...
Source: Protein Expression and Purification - Category: Biochemistry Source Type: research
This year has seen a surprising upsurge in cases of a rare viral infection in humans. Specialists warn that we need a strategy to prevent an outbreak.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Infectious Diseases / Bacteria / Viruses Source Type: news
Officials from the National Institute of Allergy and Infectious Diseases note that, as of Nov. 12, there have been 36 confirmed cases of eastern equine encephalitis this year, 14 of which were fatal.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news
Jim Whitmore, fourth generation farmer in Eu Claire, Michigan died on Saturday, becoming the sixth victim of Eastern equine encephalitis in the state amid a historic outbreak in the US.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Publication date: Available online 15 November 2019Source: Veterinary Immunology and ImmunopathologyAuthor(s): Ileana Z. Martínez, Claudia Pérez-Martínez, Luis M. Salinas, Juan F. García-Marín, Ramón A. Juste, Ana BalseiroABSTRACTSpanish goat encephalitis virus (SGEV) is a novel tick-borne flavivirus subtype, closely related to the flavivirus louping ill virus (LIV). SGEV caused a severe, acute and mortal neurological disease outbreak in northern Spain in a goat herd. In order to characterize the cell population in lesions and to determine the distribution of the inflammatory cells...
Source: Veterinary Immunology and Immunopathology - Category: Veterinary Research Source Type: research
In this study, we investigated the antiviral effect of salvianolic acid B (SalB) on EV71. SalB is a major component of the Salvia miltiorrhiza root and has been shown to be an effective treatment for subarachnoid hemorrhages, and myocardial infarctions. HeLa cells were cultured in 12-well plates and treated with SalB (100 or 10 μg/mL) and 106 PFU/mL of EV71. SalB treatment (100 µg/mL) significantly decreased the cleavage of the eukaryotic eIF4G1 protein and reduced the expression of the EV71 capsid protein VP1. In addition, SalB treatment showed a dramatic decrease in viral infection, measured by immunofluorescenc...
Source: Journal of Microbiology and Biotechnology - Category: Biotechnology Authors: Tags: J Microbiol Biotechnol Source Type: research
We reported serological and molecular detection of SLEV in a healthy population of equids and humans from rural areas in Southeast Brazil. A plaque reduction neutralization test was applied, and neutralizing antibodies were detected in 11 individuals (4.6%) and 60 horses (21.5%). A qPCR targeting the 5′UTR region and reverse transcription-PCR (RT-PCR) targeting the non-structural protein (NS5) gene were performed and three individuals tested positive in both assays. Subsequent phylogenetic analysis confirmed SLEV circulation and its findings suggest the occurrence of an asymptomatic or subclinical presence in hum...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
Years of recurring encephalitis outbreaks and high fatality rates of brain inflammation disease among children in some of India's poorest regions reveal cracks in health care system
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
More News: Encephalitis | India Health | International Medicine & Public Health | Outbreaks