Prevalence and clinical associations of Staphylococcus aureus small-colony variant respiratory infection in children with cystic fibrosis (SCVSA): a multicentre, observational study

Publication date: Available online 11 November 2019Source: The Lancet Respiratory MedicineAuthor(s): Daniel J Wolter, Frankline M Onchiri, Julia Emerson, Mimi R Precit, Michael Lee, Sharon McNamara, Laura Nay, Marcella Blackledge, Ahmet Uluer, David M Orenstein, Michelle Mann, Wynton Hoover, Ronald L Gibson, Jane L Burns, Lucas R Hoffman, Daniel J Wolter, Frankline M Onchiri, Julia Emerson, Mimi R Precit, Michael LeeSummaryBackgroundStaphylococcus aureus is the bacterium cultured most often from respiratory secretions of people with cystic fibrosis. Both meticillin-susceptible S aureus and meticillin-resistant S aureus (MRSA) can adapt to form slow-growing, antibiotic-resistant isolates known as small-colony variants that are not routinely identified by clinical laboratories. We aimed to determine the prevalence and clinical significance of S aureus small-colony variants and their subtypes among children with cystic fibrosis.MethodsThe Small Colony Variant Staphylococcus aureus (SCVSA) study was a 2-year longitudinal study of children aged 6–16 years at five US cystic fibrosis centres, using culture methods sensitive for small-colony variants. Children were eligible if they had a documented diagnosis of cystic fibrosis and a minimum of two cystic fibrosis clinic visits and two respiratory cultures in the previous 12 months at enrolment. Participants attended clinic visits quarterly, at which respiratory tract samples were taken and measures of lung function (percentage ...
Source: The Lancet Respiratory Medicine - Category: Respiratory Medicine Source Type: research

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Looking for a device to track your running routine? Or you’d like to treat yourself to a little gadget for the end of year season that will supplement your workout? Maybe you just need a little push with the help of what technology can offer to get out of your apartment and hit the running track? We’ve got you covered! We’ll list our favourite health tracking devices that we’ve tested and found appropriate for running. Fitbit Ionic: Almost perfect  The Fitbit Ionic, Fitbit’s very first fitness tracker-smartwatch hybrid, is something of a love child between Pebble and Fitbit. The dev...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Health Sensors & Trackers digital health fitness running healthcare design fitness trackers digital health sensors runner Source Type: blogs
Publication date: Available online 9 December 2019Source: PolymerAuthor(s): O.I. Timaeva, N.A. Arkharova, A.S. Orekhov, V.V. Klechkovskaya, S.P. Mulakov, G.M. Kuz'micheva, I.I. PashkinAbstractComposite hydrogels in the poly-N-vinylpyrrolidone – RE(NO3)3 × xH2O system with RE = La, Gd, Yb were prepared in various forms (native, native dried in the air, dried in air and ground into powder). They were studied by methods of wide- and small-angle X-ray scattering, differential scanning calorimetry, scanning electron microscopy, and electron microprobe analysis. The composition of native PVP and PVP with powd...
Source: Polymer - Category: Chemistry Source Type: research
Over the past few decades, antimicrobial resistance has emerged as an important threat to public health due to the global dissemination of multidrug-resistant strains from several bacterial species. This worrisome trend, in addition to the paucity of new antibiotics with novel mechanisms of action in the development pipeline, warrants the development of non-antimicrobial approaches to combating infection caused by these isolates. Monoclonal antibodies (mAbs) have emerged as highly effective molecules for the treatment of multiple diseases. However, in spite of the fact that antibodies play an important role in protective i...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
The Centers for Disease Control and Prevention (CDC) has recently identified medical devices used in the ICU as a major source of antibiotic-resistant infections. N8 Medical’s CeraShield technology may help reduce such infections by preventing fouling and formation of bacterial and fungal biofilms on device surfaces. FDA has designated the company’s CeraShield Endotracheal Tube (ETT) as a “breakthrough” device, pursuant to the 21st Century Cures Act based on its potential life-saving properties. And N8 reported that ...
Source: MDDI - Category: Medical Devices Authors: Tags: Materials Source Type: news
This study provides a promising strategy to develop hybrid nanocomposite with enhanced antibacterial efficacy and also opens a new way for the establishment of efficient therapeutic systems with reduced administration frequency as substitute of antibiotics to treat otitis media.Graphical abstract
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 9 December 2019Source: International Journal of PharmaceuticsAuthor(s): Mohammed Salih, Calvin A. Omolo, Nikhil Agrawal, Pavan Walvekar, Ayman Y. Waddad, Chunderika Mocktar, Charlotte Ramdhin, Thirumala GovenderAbstractThe global threat of antimicrobial resistant strains calls for innovative strategies to utilize nano drug delivery systems to enhance the delivery of antibiotics, thus reducing the development of resistance. Supramolecular amphiphiles that can self-assemble into nanostructures are one such nano delivery system, that are showing potential for effective drug delivery. The aim...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 9 December 2019Source: BurnsAuthor(s): Despoina Koulenti, Stijn Blot
Source: Burns - Category: Dermatology Source Type: research
MONDAY, Dec. 9, 2019 -- The risk of new superbugs that pose a threat to human health and food crops is much higher than previously thought, new genetic research shows. There's been an uptick in the number of laboratory studies showing how just one...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
INTRODUCTION: The negative impact of inhalation injuries on in-hospital outcomes for burn patients is well known, but the burns community is yet to form a consensus on diagnostic criteria and clinical definitions. The diagnosis of inhalation injuries is co...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Burns, Electricity, Explosions, Fire, Scalds Source Type: news
(Rice University) With initial support from Shell, Rice University has launched Carbon Hub, a climate change research initiative to fundamentally change how the world uses hydrocarbons. Carbon Hub's goal is a zero-emissions future in which hydrocarbons are not burned. Instead, they are split to make clean hydrogen energy and valuable carbon materials.
Source: EurekAlert! - Biology - Category: Biology Source Type: news
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