Transmission of Tuberculosis Among Illicit Drug Use Linkages

Conditions:   Tuberculosis;   Illicit Drug Use Intervention:   Behavioral: Smoked illicit drug use Sponsors:   Boston Medical Center;   University of Stellenbosch;   Desmond Tutu HIV Foundation/ University of Cape Town;   Boston University;   Medical Research Council, South Africa;   National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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CONCLUSIONS: It was revealed that conjugation of lupanes with INH at C3 is more effective than at C28 and lupane skeleton is preferable among oleanane and ursane types. The replacement of native hexacarbocyclic A ring to seven-member azepane ring is favorably for inhibition of both MTB H37RV and SDR-strains. These data could possibly mean that the antitubercular activity against INH-resistant strains (INH-R) came from both triterpenoid and isoniazid parts of the hybrid molecules. Azepanobetulin showed the highest activity against both INH-R strains in comparison with other triterpenoids and INH. Thus, the introduction of h...
Source: Medicinal Chemistry - Category: Chemistry Authors: Tags: Med Chem Source Type: research
Intravenous BCG immunization prevents or substantially limits tuberculosis in rhesus macaques, researchers report.Reuters Health Information
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Pulmonary Medicine News Source Type: news
Giving the vaccine intravenously to monkeys provided 90% protection against tuberculosis. More testing is needed before humans can be inoculated that way.
Source: NYT - Category: American Health Authors: Tags: Tuberculosis Vaccination and Immunization Monkeys and Apes Lungs Third World and Developing Countries National Institute of Allergy and Infectious Diseases University of Pittsburgh Nature (Journal) Seder, Robert A Africa your-feed-heal Source Type: news
(NIH/National Institute of Allergy and Infectious Diseases) Tuberculosis (TB), an ancient disease, is the leading infectious cause of death globally, yet the world's only licensed TB vaccine, Bacille Calmette-Guerin (BCG), was developed a century ago. Given to infants via a needle placed just under the skin, BCG protects babies from a form of the disease called disseminated TB but is far less effective at preventing pulmonary TB, the major cause of illness and deaths, in teens or adults.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
Conclusion: This study suggests the existence of different celullar patterns once the treatment has finished and supports the basis of a treatment hypothesis.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Allergy and immunology Source Type: research
Conditions:   Tuberculosis;   Illicit Drug Use Intervention:   Behavioral: Smoked illicit drug use Sponsors:   Boston Medical Center;   University of Stellenbosch;   Desmond Tutu HIV Foundation/ University of Cape Town;   Boston University;   Medical Research Council, South Africa;   National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Pradana KA, Widjaya MA, Wahjudi M Abstract In Human, Major Histocompatibility Complex known as Human Leukocyte Antigen (HLA). The HLA grouped into three subclasses regions: the class I region, the class II region, and the class III region. There are thousands of polymorphic HLAs, many of them are proven to have correlations with diseases. Indonesia consists of diverse ethnicity people and populations. It carries a unique genetic diversity between one and another geographical positions. This paper aims to extract Indonesians HLA allele data, mapping the data, and correlating them with global diseases. From ...
Source: Immunological Investigations - Category: Allergy & Immunology Tags: Immunol Invest Source Type: research
In the beginning, there were single-cell bacteria. They were the only life on earth for billions of years, then larger cells evolved, then multicellular organisms, and then plants and animals. But the bacteria never went away, and all organisms, including us humans, have had to learn to live with them. Today, the lessons they are teaching us could change the trajectory of human health for generations. When bacteria were first discovered more than three centuries ago, most attention was on the ones we fought, which caused diseases like cholera, typhoid and tuberculosis. Through vaccines and antibiotics, we have made amazing...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized medicine Source Type: news
Condition:   Tuberculosis Intervention:   Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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