A Staging System for Neuroendocrine Tumors of the Lung Needs to Incorporate Histological Grade.

CONCLUSIONS: Grade was the dominant driver of prognosis in patients with neuroendocrine tumors of the lung. Incorporation of grade with traditional TNM parameters better discriminates between stage categories compared to current AJCC staging. Future NETL staging systems should include histologic grade. PMID: 31706866 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Ann Thorac Surg Source Type: research

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Authors: Briganti V, Cuccurullo V, Berti V, Di Stasio GD, Linguanti F, Mungai F, Mansi L Abstract Neuroendocrine tumors (NETs) consist of a relatively rare spectrum of malignancies that can arise from neuroendocrine cells; lung NETs (L-NETs) represent about 25% of primary lung neoplasm and 10% of all carcinoid tumors. Diagnostic algorithm usually takes into consideration chest X-ray, contrast-enhanced CT and MRI. Nuclear medicine plays a crucial role in the detection and correct assessment of neoplastic functional status as it provides in vivo metabolic data related to the over-expression of Somatostatin Receptors ...
Source: Current Radiopharmaceuticals - Category: Radiology Tags: Curr Radiopharm Source Type: research
AbstractPurpose of ReviewPhotodynamic therapy is approved in the USA for curative treatment of microinvasive endobronchial non-small cell lung cancer and palliation of symptoms with obstructing endobronchial non-small cell lung cancer. New data support its use with positive margins after surgical resection. Emerging data suggest it is both safe and efficacious for use in the periphery with non-small cell lung cancer.Recent FindingsSeveral case series have demonstrated its utility with endobronchial disease from small cell lung cancer. Recent studies have examined its use with recurrent respiratory papillomatosis, adenoid c...
Source: Current Respiratory Care Reports - Category: Respiratory Medicine Source Type: research
CONCLUSIONSGrade was the dominant driver of prognosis in patients with neuroendocrine tumors of the lung. Incorporation of grade with traditional TNM parameters better discriminates between stage categories compared to current AJCC staging. Future NETL staging systems should include histologic grade.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Conclusion: Our data supports that never/ever smoker patients with small-cell lung cancer have better prognosis compared to their smoker counterparts. Further, patients with never/ever smoking history who present with small-cell lung cancer have a different mutation profile compared with smokers, including a high frequency of EGFR, MET, and SMAD4 mutations. Further studies are required to assess whether the differential mutation profile is a consequence of a diverse pathological mechanism for disease onset. Introduction Lung cancer is the most common neoplasia worldwide. Aside from the high incidence, lung cancer a...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Authors: Shende P, Augustine S, Prabhakar B, Gaud RS Abstract INTRODUCTION: Lung cancer (LC) emerges as a principle cause of death among smokers and is also one of the most lethal forms of cancer in non-smokers. LC is mainly classified as non-small cell lung cancer (NSCLC), small cell lung cancer and lung carcinoid tumor. NSCLC is the most prevalent form of LC and its early stage diagnosis is essential to reduce mortality rate of patients and provide specific therapy. The field of LC diagnostics witnessed a gradual escalation with advancement in technology. Areas covered: This comprehensive review focuses on classi...
Source: Expert Review of Molecular Diagnostics - Category: Laboratory Medicine Tags: Expert Rev Mol Diagn Source Type: research
This study evaluated its diagnostic value for differentiating between NSCLC and high-grade neuroendocrine tumor (HGNET).MethodsStathmin-1 protein expression was assessed by immunohistochemistry (IHC) in surgical specimens of 414 NSCLC (305 adenocarcinoma [AD], 102 squamous cell carcinoma [SCC], 7 large-cell carcinoma [LA]), 5 typical carcinoid (TC; a low-grade neuroendocrine tumor), and 34 HGNET (17 small-cell carcinoma [SCLC] and 17 large-cell neuroendocrine carcinoma [LCNEC]) and biopsy specimens of 57 NSCLCs (29 AD and 28 SCC) and 42 HGNETs (17 LCNEC and 25 SCLC). We also analyzed stathmin-1 mRNA levels in 81 NSCLC and ...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
1373Objectives: To collect preliminary data on 82-Rb (Rb) uptake in malignant tumors on PET/CT. Methods: The data warehouse of our institution was searched for all patients with a histologically proven, untreated malignancy at the time of cardiac Rb PET/CT since its introduction in October 2008 until August 31, 2015 . Two radiologists reviewed Rb PET/CT images and compared Rb uptake of the dominant lesion (LIS) in each patient to the Rb uptake in the liver (LIV), mediastinum blood pool (MBP), lung (LUN) and subcutaneous fat uptake (SCF). Lesion uptake was scored as 4 (LIS> LIV), 3 (LIV> LIS> MBP), 2 (MBP> LIS&g...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Other Solid Tumors Posters Source Type: research
Abstract Mixed morphology lung tumors are rare; this is the second report of a combined NSCLC and atypical carcinoid tumor. Next generation sequencing was performed on both histologically distinct patterns which identified that both components harbored a BRAF p.V600E mutation. Molecular studies inform our knowledge of the biology and aid in treatment decisions for mixed morphology lung cancers. PMID: 29248665 [PubMed - as supplied by publisher]
Source: Experimental and Molecular Pathology - Category: Pathology Authors: Tags: Exp Mol Pathol Source Type: research
AbstractMetastatic tumors to the breast are rare but constitute a major diagnostic dilemma. Of these, non-mammary carcinomatous metastases to the breast are particularly challenging and, without a clinical history, may be extremely difficult to distinguish from primary breast carcinoma (PBC). We specifically studied metastatic tumors of pulmonary origin, as the lung is one of the major primary sites for carcinomatous metastasis to breast. Sixteen metastatic lung tumors to the breast were identified in our archives between 1996 and 2017 including 12 non-small cell lung carcinomas (NSCLC), one large-cell neuroendocrine, one ...
Source: Virchows Archiv - Category: Pathology Source Type: research
88The authors declare no conflicts of interest. Support This work was also supported in part by Health and Family Planning Commission of Shanxi Province Foundation (2015036) This work was supported in part by a grant from University of science and technology innovation projects in Shanxi Province (20141101) This work was supported in part by a grant from Youth Innovation Fund of The First Hospital of Shanxi Medical University(YC1424) This work was supported in part by a grant from Youth Innovation Fund of Shanxi Medical University(01201415) This work was supported in part by a grant from Youth of Basic Research Project of ...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Lung Cancer I Source Type: research
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