Day Case Radioiodine for Thyroid Cancer Safe and Feasible Day Case Radioiodine for Thyroid Cancer Safe and Feasible

Lower dose radioiodine ablation in thyroid cancer patients means a significant proportion could be treated as day cases, freeing up hospital beds and offering cost savings, suggest UK study findings.Medscape News UK
Source: Medscape Radiology Headlines - Category: Radiology Tags: Hematology-Oncology News Source Type: news

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We report FDG PET/CT images of a 63-year-old woman referred for characterization of osteolytic lesions of the cervical spine. This patient with chronic renal failure had a history of follicular thyroid carcinoma with undifferentiated cells, treated by a total thyroidectomy, completed by radioactive iodine in 2017. Because of cancer history, a FDG PET/CT was performed and showed multiple moderately hypermetabolic osteolytic lesions of the spine from C3 to T1, with joint erosion on CT. A laminectomy was performed for cervical spinal cord decompression and revealed a gouty tophus.
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Interesting Images Source Type: research
ConclusionsThe paucity of studies about GPER1 in the thyroid, as well as methodological differences between them, precludes firm conclusions about GPER1 role in the thyroid, although there are some evidences of GPER1-induced proliferation of thyroid cancer cells.Graphical abstract
Source: Life Sciences - Category: Biology Source Type: research
Thyroid, Ahead of Print.
Source: Thyroid - Category: Endocrinology Authors: Source Type: research
Publication date: Available online 6 December 2019Source: Molecular and Cellular EndocrinologyAuthor(s): Giacomo Lettini, Michele Pietrafesa, Silvia Lepore, Francesca Maddalena, Fabiana Crispo, Alessandro Sgambato, Franca Esposito, Matteo LandriscinaAbstractThyroid cancer is the most common endocrine malignancy, with well-differentiated subtypes characterized by an excellent prognosis due to their optimal sensitivity to standard therapies whereas poorly differentiated and anaplastic tumours by chemo/radio-resistance and unfavourable outcome. Heat Shock Proteins (HSPs) are molecular chaperones overexpressed in thyroid malig...
Source: Molecular and Cellular Endocrinology - Category: Endocrinology Source Type: research
CONCLUSIONS: DNA methylation levels of three markers can be useful for differentiating differentiated thyroid cancer from non-malignant follicular thyroid lesions, and may serve as prognostic biomarkers for predicting recurrent or persistent disease following surgery for differentiated thyroid cancer. PMID: 31797753 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
The objective of the current study was to determine if the development of thyroid cancer is associated with a differential survival in radiation-exposed individuals. METHODS: We conducted a matched prospective cohort mortality follow-up study based on data from a cohort of 4296 individuals who were irradiated for enlarged tonsils during their childhood (between 1939 and 1962) and were prospectively followed since 1974. The study matched an irradiated subject who developed (was exposed to) thyroid cancer (a "case") and two irradiated subjects, who had not developed (were not exposed to) thyroid cancer ("c...
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
Thyroid, Ahead of Print.
Source: Thyroid - Category: Endocrinology Authors: Source Type: research
AbstractIn patients with thyroid fine-needle aspiration (FNA) report of suspicious for malignancy (SFM), both lobectomy and thyroidectomy might be considered. BRAF mutation analysis could guide towards accurate surgical therapy. The primary outcome was the reliability of BRAF (V600E) in detecting malignancy in nodules with FNA reading of SFM. The secondary outcome was to analyze its positive predictive value (PPV) and negative predictive value (NPV) considering the surgical histology as gold standard. A literature search of online databases was performed in June 2019. BRAF prevalence among thyroid nodules with FNA read as ...
Source: Endocrine Pathology - Category: Pathology Source Type: research
A 75-year-old lady with previously diagnosed moderate mixed aortic valve disease underwent surveillance transthoracic echocardiography (TTE). This showed raised trans-aortic gradients in the presence of normal aortic valve leaflet motion and turbulent colour flow across a calcified left ventricular outflow tract (LVOT). Therefore, in view of possible subaortic stenosis, she was referred for cardiac computed tomography for further characterisation. Past medical history included total thyroidectomy and 2 rounds of radioiodine ablation for follicular thyroid carcinoma 12 months prior.
Source: Journal of Cardiovascular Computed Tomography - Category: Radiology Authors: Source Type: research
Publication date: Available online 3 December 2019Source: Journal of Molecular StructureAuthor(s): Bao-Li Wang, Song-Bo Kou, Zhen-Yi Lin, Jie-Hua ShiAbstractLenvatinib was a multi-tyrosine kinase inhibitor (TKI) used for treating advanced renal cell carcinoma and differentiated thyroid cancer. Multiple fluorescence spectroscopy including SSF, SF, 3DF, UV, FTIR, and molecular modeling were utilized for better understanding the binding interaction between lenvatinib and bovine serum albumin (BSA). SSF spectroscopy results showed lenvatinib quenched the intrinsic fluorescence of BSA in the form of the mixed mechanism. The bin...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
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