Clinical Neurorestorative Therapeutic Guidelines for Spinal Cord Injury (IANR/CANR version 2019)
Publication date: Available online 11 November 2019Source: Journal of Orthopaedic TranslationAuthor(s): Hongyun Huang, Wise Young, Stephen Skaper, Lin Chen, Gustavo Moviglia, Hooshang Saberi, Ziad Al-Zoubi, Hari Shanker Sharma, Dafin Muresanu, Alok Sharma, Wagih El Masry, Shiqing Feng, International Association of Neurorestoratology and The Chinese Association of NeurorestoratologyAbstractFunctional restoration after spinal cord injury (SCI) is one of the most challenging tasks in neurological clinical practice. With a view to exploring effective neurorestorative methods in the acute, subacute, and chronic phases of SCI, “Clinical Therapeutic Guidelines of Neurorestoration for Spinal Cord Injury (China Version 2016)” was first proposed in 2016 by the Chinese Association of Neurorestoratology (CANR). Given the rapid advances in this field in recent years, the International Association of Neurorestoratology (IANR) and CANR formed and approved the “Clinical Neurorestorative Therapeutic Guidelines for Spinal Cord Injury (IANR/CANR version 2019)”. These guidelines mainly introduce restoring damaged neurological structure and functions by varying neurorestorative strategies in acute, subacute, and chronic phases of SCI. These guidelines can provide a neurorestorative therapeutic standard or reference for clinicians and researchers in clinical practice to maximally restore functions of patients with SCI and improve their quality of life.
Conclusion: These results suggested that DUSP19-mediated SCI-induced apoptosis and inflammation via NF-κB signaling and might therefore serve as a potential therapeutic target for SCI. PMID: 31813339 [PubMed - as supplied by publisher]
Condition: Spinal Cord Injuries Interventions: Device: 20 Hz rTMS (Brain); Device: iTBS rTMS (Brain); Device: Anode tsDCS (Spinal); Device: 20 Hz current square-wave pulses (Spinal); Device: iTBS (Spinal); Device: sham Sponsor: Taipei Medical University Hospital Not yet recruiting
After complete spinal cord injury, mammals, including mice, rats and cats, recover hindlimb locomotion with treadmill training. The premise is that sensory cues consistent with locomotion reorganize spinal sensorimotor circuits. Here, we show that hindlimb standing and locomotion recover after spinal transection in cats without task-specific training. Spinal-transected cats recovered full weight bearing standing and locomotion after five weeks of rhythmic manual stimulation of triceps surae muscles (non-specific training) and without any intervention. Moreover, cats modulated locomotor speed and performed split-belt locomo...
Spinal Cord, Published online: 11 December 2019; doi:10.1038/s41393-019-0394-xA comparative examination of models of service delivery intended to support community integration in the immediate period following inpatient rehabilitation for spinal cord injury
Spinal Cord, Published online: 11 December 2019; doi:10.1038/s41393-019-0393-yMultidrug-resistant gram-negative organisms and association with 1-year mortality, readmission, and length of stay in Veterans with spinal cord injuries and disorders
Publication date: Available online 9 December 2019Source: Neuroscience LettersAuthor(s): Tianzun Li, Rui Xu, Haijian Xia, Xiaojun Hu, Shengxi Wang, Yang Li, Yi Yan, Yongzhi XiaAbstractApoptosis signal-regulating kinase 1 (ASK1) may play a pivotal role in reactive gliosis. To assess the role of ASK1 in trauma-induced reactive gliosis, we examined the phosphorylation of ASK1 and the expression of glial fibrillary acidic protein (GFAP) and vimentin after scratch injury in cultured astrocytes and spinal cord injury (SCI) in rats. Enhanced phosphorylation of ASK1 was detected during reactive gliosis both in vitro and in ...
Conditions: Urinary Bladder, Neurogenic; Blood Pressure; Autonomic Dysreflexia; Bowel Incontinence Intervention: Device: Spinal Cord Epidural Stimulation Sponsors: University of Louisville; National Institutes of Health (NIH) Not yet recruiting
Conclusion/Clinical Relevance: The case demonstrated that refractory AD could be managed with ITB in an emergency. PMID: 31815605 [PubMed - as supplied by publisher]
(Kessler Foundation) Dr. Zanca has contributed to a system for classifying rehabilitation interventions with support from NIDILRR and the Patient-Centered Outcomes Research Institute. She is co-investigator for the NIDILRR-funded Northern New Jersey Spinal Cord Injury System, and co-chair of the national Spinal Cord Injury Model System (SCIMS) Knowledge Translation Committee. She is author/co-author of more than 20 peer-reviewed publications and an associate editor for the Journal of Spinal Cord Medicine, official journal of the Academy of Spinal Cord Injury Professionals.
Spinal Cord, Published online: 10 December 2019; doi:10.1038/s41393-019-0395-9The beneficial aspects of spasticity in relation to ambulatory ability in mice with spinal cord injury