Rice (Oryza sativa japonica) albumin hydrolysates suppress postprandial blood glucose elevation by adsorbing glucose and inhibiting Na+-d-glucose cotransporter SGLT1 expression

Publication date: Available online 11 November 2019Source: Journal of Functional FoodsAuthor(s): Shigenobu Ina, Aya Hamada, Hanae Nakamura, Yusuke Yamaguchi, Hitoshi Kumagai, Hitomi KumagaiAbstractThe mechanism of the suppressive effect of rice albumin (RA) on postprandial hyperglycemia after glucose loading was investigated. In order to examine if small peptides derived from RA are responsible for prevention of postprandial hyperglycemia, RA was hydrolysed to indigestible high-molecular-weight peptides (HMP) and low-molecular-weight peptides (LMP) by trypsin, HMP and LMP being fractionated by gel-filtration chromatography. In oral glucose tolerance test (OGTT), both HMP and LMP suppressed the increase in blood glucose levels. In vitro diffusion test results showed that HMP adsorbed glucose and retarded its diffusion rate like dietary fibers. On the other hand, LMP suppressed the expression of sodium-dependent glucose transporter-1 (SGLT1) in STC-1 cells. Therefore, the suppressive effect of RA on postprandial hyperglycemia would be due to the dual actions of HMP and LMP. Our results demonstrated the potential use of RA as a functional food material to prevent diabetes.Graphical abstract
Source: Journal of Functional Foods - Category: Nutrition Source Type: research

Related Links:

CONCLUSIONS Silicone oil endotamponade in PPV was associated with an increased risk of IOP at 24-month follow-up. PMID: 31811816 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Publication date: Available online 9 December 2019Source: Journal of Functional FoodsAuthor(s): Milkica Grabež, Ranko Škrbić, Miloš P. Stojiljković, Vesna Rudić-Grujić, Marija Paunović, Aleksandra Arsić, Snježana Petrović, Vesna Vučić, Bosa Mirjanić-Azarić, Katarina Šavikin, Nebojša Menković, Teodora Janković, Nađa VasiljevićAbstractPomegranate peel contains high levels of various phytochemicals. We evaluated the effects of pomegranate peel extract (PoPEx) consumption on plasma lipid profile, fatty acids (FA) level and blood pressure (BP) in patients with diabetes mellitus type ...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
But the new guidance may not have a big impact on price, despite the agency's pronouncements.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news
ConclusionsThe use of the tesaglitazar-[F7, P34]-NPY conjugate is a promising strategy to apply the beneficial PPARα/γ effects in adipocytes while potentially omitting adverse effects in other tissues.Graphical abstract
Source: Molecular Metabolism - Category: Endocrinology Source Type: research
ConclusionsWhile based on a small number of studies, the review establishes moderate evidence that interventions to improve cultural safety can have positive effects on the treatment of diabetes in Indigenous populations. Further research with stronger study designs should be conducted to further validate the present conclusions.
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
Publication date: Available online 9 December 2019Source: Canadian Journal of DiabetesAuthor(s): Lingning Huang, Yongze Zhang, Yunmin Wang, Ximei Shen, Sunjie YanAbstractAimsInvestigate association between diabetic peripheral neuropathy (DPN)and above normal blood pressure in non-hypertensive patients with type 2 diabetes mellitus(T2DM). Compare the achievement of clinical target for DPN and non-DPN withT2DM .MethodsA retrospective survey was administered to 3810 patients with type 2 diabetes. Cases were grouped according to the Toronto Clinical Scoring System (TCSS): Non-DPN, Mild DPN, Moderate DPN and Severe DPN. 1835 pa...
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
Diabetes Dad Brendan McEachern in Cincinnati has written a book from the perspective of an 11-year-old with type 1 diabetes.
Source: Diabetes Mine - Category: Endocrinology Authors: Source Type: blogs
Abstract Brachychiton populneus (Schott&Endl.) R.Br., Malvaceae, is one of five Brachychiton species cultivated in Egypt. Little information was found concerning the morphological, phytochemical and biological investigations of B. populneus. Morphological investigations of B. populneus were performed on fresh and dried leaves. Air-dried, ground leafy branches were extracted with 70% methanol/water yielding B. populneus extract. Seventeen flavonoids were isolated and identified using different chromatographic and spectroscopic techniques; eleven of them were reported for the first time from this plant. Potential activit...
Source: Revista Brasileira de Farmacognosia - Category: Drugs & Pharmacology Source Type: research
In this study, extracts of Trapa natans pericarp were tested both in vitro and in vivo through a high-fat diet with a single medium dosage streptozotocin injection induced type 2 diabetic mice. Different solvent extracts of Trapa natans pericarp showed α -amylase and α -glucosidase inhibitory activity. After four weeks administration, the ethyl acetate extract of Trapa natans pericarp (50 and 100 mg/kg b.w.) reduced fasting blood glucose level, ameliorated oral glucose tolerance and insulin resistance, improved serum lipids alterations in type 2 diabetic mice as well. Additionally, ethyl acetate extract signifi...
Source: Revista Brasileira de Farmacognosia - Category: Drugs & Pharmacology Source Type: research
Abstract This paper presents the first comprehensive report on traditional uses of medicinal shrubs of Rawalakot city, district Poonch, Azad Jammu and Kashmir, Pakistan. Ethobotanical data obtained from 120 informants were analyzed by relative frequency citation, use value, family use value, informant consensus factor, fidelity level and Jaccard index. In total, 41 shrubs belonging to 24 families and 34 genera were documented. Rosaceae was reported the most dominant family in the area (six species) and Berberidaceae showed maximum family use value (0.68). Leaves (35%) and fruits (33%) were the most commonly used plant part...
Source: Revista Brasileira de Farmacognosia - Category: Drugs & Pharmacology Source Type: research
More News: Diabetes | Diets | Endocrinology | Nutrition | Sodium