Hyperhomocysteinemia induced locked-in syndrome in a young adult due to folic acid deficiency
This study demonstrates that body part-specific somatosensory imagery differentially activates somatosensory cortex in a topographically specific manner; evidence which was surprisingly still lacking in the literature. It also offers proof of concept for a novel somatosensory imagery-based fMRI-BCI control strategy, with particularly high potential for visually and motor-impaired patients. The strategy could also be transferred to lower MRI field strengths and to mobile functional near-infrared spectroscopy. Finally, given that communication BCIs provide the BCI user with a form of feedback based on their brain signals and...
The unidentified patient, from Maryland, suffered a rare but devastating brain-stem stroke which paralysed her from head-to-toe. She was diagnosed with locked-in syndrome.
ConclusionOur patient developed locked-in syndrome after use of cocaine. Given the prevalence of its use in the United States, cocaine use should be included among the potential causes of locked-in syndrome.
Publication date: Available online 16 November 2019Source: Brain StimulationAuthor(s): Takeshi Satow, Taro Komuro, Takuya Yamaguchi, Nobuhiko Tanabe, Tatsuya Mima
New Zealand pharmacist Anstey Campbell decided to start the morning of January 17 with a light jog before heading off to work, noticing that the prickling sensation hadn't subsided by lunchtime.
Publication date: Available online 2 November 2019Source: Annals of Physical and Rehabilitation MedicineAuthor(s): Yifan Yan, Athena Demertzi, Yinyan Xia, Jing Wang, Nantu Hu, Zhiliang Zhang, Haibo Di, Steven LaureysAbstractBackgroundLocked-in syndrome (LIS) characterizes individuals who have experienced pontine lesions, who have limited motor output but with preserved cognitive abilities. Despite their severe physical impairment, individuals with LIS self-profess a higher quality of life than generally expected. Such third-person expectations about LIS are shaped by personal and cultural factors in western countries.Objec...
Conclusion: Bilateral cerebral peduncle infarction may be related to cerebral perfusion insufficiency caused by the stenosis or occlusion of vertebrobasilar artery and its branches. The main clinical manifestations are locked-in syndrome and persistent vegetative state. The specific imaging feature of “Mickey Mouse ear”-like infarction is associated with a poor prognosis.
Peter Coghlan, of Manchester, was diagnosed with locked-in syndrome in 2011. At his lowest point, he didn't want to live, but he turned his recovery around.
Conclusions Our results indicate that anti–pan-NF-associated neuropathy differs from anti–NF-155-associated neuropathy, and epitope and subclass play a major role in the pathogenesis and severity of anti–NF-associated neuropathy and should be determined to correctly classify patients, also in respect to possible differences in therapeutic response.
Publication date: Available online 12 August 2019Source: Brain StimulationAuthor(s): Zhenchao Huang, Xiaofeng Xu, Qing Dong, Lei Wei, Yanjun Lin, Ju Jiao, Zhengqi Lu, Feng Qin