Characterization of Epileptic Spiking Associated With Brain Amyloidosis in APP/PS1 Mice

Epileptic activity without visible convulsions is common in Alzheimer's disease (AD) and may contribute adversely to the disease progress and symptoms. Transgenic mice with amyloid plaque pathology also display epileptic seizures, but those are too infrequent to assess the effect of anti-epileptic treatments. Besides spontaneous seizures, these mice also display frequent epileptic spiking in epidural EEG recordings, and these have provided a means to test potential drug treatment to AD-related epilepsy. However, the origin of EEG spikes in transgenic AD model mice has remained elusive, which makes it difficult to relate electrophysiology with underlying pathology at the cellular and molecular level. Using multiple cortical and subcortical electrodes in freely moving APP/PS1 transgenic mice and their wild-type littermates, we identified several types of epileptic spikes among over 15 800 spikes visible with cortical screw electrodes based on their source localization. Cortical spikes associated with muscle twitches, cortico-hippocampal spikes, and spindle and fast-spindle associated spikes were present equally often in both APP/PS1 and wild-type mice, whereas pure cortical spikes were slightly more common in APP/PS1 mice. In contrast, spike-wave discharges, cortico-hippocampal spikes with after hyperpolarization and giant spikes were seen almost exclusively in APP/PS1 mice but only in a subset of them. Interestingly, different subtypes of spikes responded differently to anti-e...
Source: Frontiers in Neurology - Category: Neurology Source Type: research

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Resumo Este artigo tem por base uma investiga ção realizada entre novembro de 2013 e janeiro de 2017, na Universidade do Minho (Portugal), sobre os docentes da Universidade Óscar Ribas (UOR) (Angola). Foi alicerçado num referencial teórico, a Psicodinâmica do Trabalho de Christophe Dejours, e teve como objetivos analisar os sintomas biops icossociais e os sentimentos de prazer e/ou de sofrimento relacionados com o trabalho docente. Foi utilizada a metodologia quantitativa, que teve por base a aplicação de um questionário e duas escalas a 56 docentes da UOR. Veri...
Source: Saude e Sociedade - Category: International Medicine & Public Health Source Type: research
ConclusionsFurther research exploring concurrent changes in all movement behaviours (PA, SB and sleep) and associated factors is warranted to inform future behavioural interventions and policies for promoting an optimal 24-h movement behaviour pattern during this critical developmental period.
Source: Journal of Science and Medicine in Sport - Category: Sports Medicine Source Type: research
Publication date: Available online 9 December 2019Source: Social Science &MedicineAuthor(s): Maddalena Canna, Rebecca SeligmanAbstractFunctional Neurological Disorder (FND), otherwise known as Conversion Disorder, is characterized by abnormal sensory or motor symptoms that are determined to be “incompatible” with neurological disease. FND patients are a challenge for contemporary medicine. They experience high levels of distress, disability, and social isolation, yet a large proportion of those treated do not get better. Patients with FNDs are often misdiagnosed and suffer from stigma, dysfunctional medical...
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research
Insomnia and co-existing sleeplessness and musculoskeletal pain were inversely related to long-term recovery from chronic low back pain, a study found; relieving sleep problems may improve recovery.Medscape Medical News
Source: Medscape FamilyMedicine Headlines - Category: Primary Care Tags: Internal Medicine News Source Type: news
The Walt Disney Company issued a warning for the new 'Star Wars: The Rise of Skywalker' movie, citing it may trigger seizures for those with epilepsy due to flashing lights.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
ConclusionNewly available evidence supports earlier findings that cannabidiol probably reduces the frequency of seizures among children with drug-resistant epilepsy.PROSPEROCRD42018084755
Source: Seizure - Category: Neurology Source Type: research
Publication date: Available online 9 December 2019Source: Epilepsy &BehaviorAuthor(s): Rhys H. Thomas, Donald P. Craig, John Paul LeachAbstractA sudden epilepsy-associated death is a tragedy for the bereaved, a failure for the clinician and a challenge for a research scientist. Sudden death in epilepsy cannot be truly anticipated or prepared for by the bereaved, or the clinical team. Communications and provision of pastoral care following sudden unexpected death in epilepsy (SUDEP) is an important part of an epilepsy service where interaction with the family and specialist services for the bereaved can be rewarding. Su...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
ConclusionA judicious analysis of the features on which the historians and literati based their suspicion to label The Prophet epileptic, provides little supportive evidence when analyzed from a neurological perspective. Without judicious analysis of clinical data chances of misdiagnosis tend to be fairly high.
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
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Source: NYT Health - Category: Consumer Health News Authors: Tags: Apnea (Sleep Disorder) Health Insurance and Managed Care Traffic Accidents and Safety Snoring Source Type: news
Condition:   Mild Cognitive Impairment Interventions:   Drug: T-817MA;   Drug: Placebo Sponsor:   FUJIFILM Toyama Chemical Co., Ltd. Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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