Observational multicentre study into the use of antiepileptic drugs in Spanish neurology consultations

ConclusionsThe majority of patients received new AEDs. The combination of classic and new AEDs was more frequently prescribed to patients with refractory epilepsy or with associated comorbidities.ResumenObjetivoCuantificar el tipo de fármacos antiepilépticos (FAEs), empleados en epilepsia, en consultas de neurología.Material y métodoEstudio descriptivo observacional sobre una muestra de 559 pacientes mayores de 14 años con epilepsia y en tratamiento farmacológico, recogidos en consultas ambulatorias por 47 neurólogos en España en mayo del año 2016.Para las clasificaciones clínicas de la epilepsia se utilizaron las de la Liga Internacional contra la Epilepsia.Los FAEs se clasificaron según el año de comercialización: clásicos (anteriores al 1990) y nuevos (los posteriores).Se realiza análisis descriptivo de las variables cualitativas y cuantitativas.ResultadosDemográficos: 54,6% mujeres; edad media 42,7 años; edad media de inicio de la epilepsia 22,4 años.ClínicosPredominan las crisis parciales: 75,7%; sintomáticas: 51,5% y con epilepsia farmacoresistente: 32,4%. Pacientes libres de crisis en el último año 35,6%.Comorbilidad asociada 59,2 %. Tratamiento: Número de FAEs empleados 1103; 64,6% FAEs nuevos. 85,4% de los pacientes tratados con FAEs nuevos. La media y rango de FAEs empleados: 2 (1–5). 59,6% recib&iacut...
Source: Neurologia - Category: Neurology Source Type: research

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Publication date: January 2020Source: Epilepsy &Behavior, Volume 102Author(s): Roderick Duncan, John Horwood, Saif Razvi, Sharon MulhernAbstractObjectiveSome patients with psychogenic nonepileptic seizures (PNES) remit when given the diagnosis. It is not realistically possible to test this potential therapeutic effect in an Randomized Controlled Trial (RCT) so we aim to statistically demonstrate it using the temporal relationship between the communication of the diagnosis and the timing of remission.MethodRe-analysis of data from a study of PNES, where diagnosis was communicated, and outcomes recorded in 54 patients. M...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Publication date: January 2020Source: Epilepsy &Behavior, Volume 102Author(s): Niels Hansen, Kerstin Schwing, Demet Önder, Guido Widman, Pitshaporn Leelaarporn, Indra Prusseit, Rainer Surges, Nico Melzer, Catharina Gross, Albert J. Becker, Juri-Alexander Witt, Christian E. Elger, Christoph HelmstaedterAbstractPurposeInvestigating immune cells in autoimmune limbic encephalitis (LE) will contribute to our understanding of its pathophysiology and may help to develop appropriate therapies. The aim of the present study was to analyze immune cells to reveal underlying immune signatures in patients with temporal lobe epi...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
ConclusionThe RINCH motions are a common sign in focal seizures and should be distinguished from other types of manual automatism as they carry a strong lateralizing value.
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
A 6-year-old girl with a history of epilepsy was referred due to a mandibular lesion. Physical examination revealed the presence of sebaceous nevi involving skin of the face and neck. Intraoral exam revealed an asymptomatic swelling, firm to palpation, covered by mucosa of normal color, in the anterior mandible. The cone beam tomography revealed a presence of 3 well-defined mixed images, associated with impacted teeth 81, 82, and 42. The lesions were surgically excised and the histologic diagnosis was of adenomatoid odontogenic tumors (AOTs).
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Source Type: research
This case report describes a 12-year-old child diagnosed with cerebral palsy who was attended in the dental service in October 2012 with a chief complaint of caries. The dental history revealed that the child had difficulty in opening his mouth, chewing, and swallowing. In the intraoral examination, the patient had an atretic palate, fibrous gingiva, gingival bleeding, malocclusion, and presence of calculus in the supra and subgingival regions and presented epilepsy and low weight. In the complementary examinations, blood pressure was checked and the blood count was read.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Source Type: research
Publication date: Available online 13 December 2019Source: NeuroImage: ClinicalAuthor(s): Erik Kaestner, Akshara R. Balachandra, Naeim Bahrami, Anny Reyes, Sanam J. Lalani, Anna Christina Macari, Natalie L. Voets, Daniel L. Drane, Brianna M. Paul, Leonardo Bonilha, Carrie R. McDonaldABSTRACTObjectiveThe distributed white matter network underlying language leads to difficulties in extracting clinically meaningful summaries of neural alterations leading to language impairment. Here we determine the predictive ability of the structural connectome (SC), compared with global measures of white matter tract microstructure and cli...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
DiscussionResults of the selected studies are only partially comparable or generalizable because of differences in study design. They have a risk for potential biases, although they provide (if analyzed) readily available prognostic factors, easy to apply in clinical practice. Prospective, population-based studies with EEG-defined NS are warranted in order to produce evidence-based guidance for management of preterm newborns with seizures.
Source: Seizure - Category: Neurology Source Type: research
ConclusionsThis is the largest cohort of Dravet patients from within the US to report medication response with respect to genotype. Missense variants in SCN1A were most common in the voltage sensor and pore domains. All patients were most likely to respond to the recommended medication triad compared to other antiepileptic therapies.
Source: Seizure - Category: Neurology Source Type: research
We report the case of a 3-year-old boy with a history of frequent and injurious sleep-related rhythmic movements and sleep terrors. We documented six episodes of body rocking and head banging via video polysomnography. No epileptic seizures were observed. In addition to the association between a sleep movement disorder and a disorder of arousal, our case shows that sleep-related rhythmic movements can arise not only during relaxed wakefulness or during a stable sleep stage, but also during a less clearly defined sleep stage during which it is difficult to further subtype non-rapid eye movement sleep. On the contrary, the p...
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research
This study shows that possibility of changes in extracellular matrix molecules due to astrocyte activation is associated with epilepticus in PTZ-kindled mice. PMID: 31827499 [PubMed - in process]
Source: Neural Plasticity - Category: Neurology Authors: Tags: Neural Plast Source Type: research
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