The Parkinson's Disease-Related Protein DJ-1 Protects Dopaminergic Neurons in vivo and Cultured Cells from Alpha-Synuclein and 6-Hydroxydopamine Toxicity.

Conclusion: DJ-1 appears to have a protective role against dopaminergic degeneration triggered by α-syn or 6-OHDA, reinforcing the possible therapeutic importance of this protein in PD. © 2014 S. Karger AG, Basel.
PMID: 25500798 [PubMed - as supplied by publisher]

Source: Neuro-Degenerative Diseases - December 11, 2014 Category: Neurology Authors: Batelli S, Invernizzi RW, Negro A, Calcagno E, Rodilossi S, Forloni G, Albani D Tags: Neurodegener Dis Source Type: research