Proteomic research in sarcomas – current status and future opportunities

Publication date: Available online 10 November 2019Source: Seminars in Cancer BiologyAuthor(s): Jessica Burns, Christopher P Wilding, Robin L Jones, Paul H HuangAbstractSarcomas are a rare group of mesenchymal cancers comprising over 70 different histological subtypes. For the majority of these diseases, the molecular understanding of the basis of their initiation and progression remains unclear. As such, limited clinical progress in prognosis or therapeutic regimens have been made over the past few decades. Proteomics techniques are being increasingly utilised in the field of sarcoma research. Proteomic research efforts have thus far focused on histological subtype characterisation for the improvement of biological understanding, as well as for the identification of candidate diagnostic, predictive, and prognostic biomarkers for use in clinic. However, the field itself is in its infancy, and none of these proteomic research findings have been translated into the clinic. In this review, we provide a brief overview of the proteomic strategies that have been employed in sarcoma research. We evaluate key proteomic studies concerning several rare and ultra-rare sarcoma subtypes including, gastrointestinal stromal tumours, osteosarcoma, liposarcoma, leiomyosarcoma, malignant rhabdoid tumours, Ewing sarcoma, angiosarcoma, myxofibrosarcoma, and alveolar soft part sarcoma. Consequently, we illustrate how routine implementation of proteomics within sarcoma research, integration of pro...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research

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Publication date: Available online 4 December 2019Source: The Lancet Global HealthAuthor(s): Marc Arbyn, Elisabete Weiderpass, Laia Bruni, Silvia de Sanjosé, Mona Saraiya, Jacques Ferlay, Freddie BraySummaryBackgroundThe knowledge that persistent human papillomavirus (HPV) infection is the main cause of cervical cancer has resulted in the development of prophylactic vaccines to prevent HPV infection and HPV assays that detect nucleic acids of the virus. WHO has launched a Global Initiative to scale up preventive, screening, and treatment interventions to eliminate cervical cancer as a public health problem during th...
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
Publication date: Available online 4 December 2019Source: The Lancet Global HealthAuthor(s): Afsan Bhadelia
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
BACKGROUND: Burn injuries are the third leading cause of preventable death in children worldwide, resulting in over 100  000 annual hospitalisations. In the paediatric population, scalds are the commonest mechanism and burn injuries of greater than 40% to...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news
Blast-induced tinnitus is a prevalent problem among military personnel and veterans, as blast-related trauma damages the vulnerable microstructures within the cochlea, impacts auditory and non-auditory brain structures, and causes tinnitus and other disord...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Burns, Electricity, Explosions, Fire, Scalds Source Type: news
BACKGROUND: Epidemiological studies focusing on occupational pathologies can be an important medium through which to bring about change with respect to workplace accidents, both in terms of prevention planning and management as well as the appropriate care...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Burns, Electricity, Explosions, Fire, Scalds Source Type: news
CONCLUSIONS: Both low and high Hgb levels were associated with an increased risk of death from various causes, and some diseases showed different patterns according to sex. PMID: 31795616 [PubMed - in process]
Source: Journal of Preventive Medicine and Public Health - Category: International Medicine & Public Health Tags: J Prev Med Public Health Source Type: research
A new "virtual biopsy" using ultrasound guidance allows doctors to definitively...Read more on AuntMinnie.comRelated Reading: USPSTF again dismisses pancreatic cancer screening New class of radiotracers targets many cancer types Can radiomics detect pancreatic ductal adenocarcinoma? Optical imaging finds small tumors
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
CHICAGO - What are the distinct benefits of 3D printing and augmented reality...Read more on AuntMinnie.comRelated Reading: 3D printing helps unravel rare cardiac anomalies 4 core applications of cardiovascular 3D printing AR, 3D printing enhance planning for complex heart surgery AR, 3D printing aid presurgical planning for kidney cancer 3D printing gives pediatric heart surgery a boost
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
A shorter round of higher-dose radiation to part of the breast demonstrates...Read more on AuntMinnie.comRelated Reading: ASTRO: Whole, partial breast RT yield similar cosmetic results Stereotactic radiation extends long-term survival ASTRO: Breast radiation 'less scary' than expected ASTRO releases updated APBI guide
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Researchers from Washington University in St. Louis have developed a new imaging...Read more on AuntMinnie.comRelated Reading: Optical imaging technique better predicts heart attacks Is an accurate two-minute biopsy viable? Skin imaging firm lauds CPT recommendation for OCT Australian group develops new optical breast imaging technique
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
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