Prehabilitation for patient positioning: pelvic exercises assist in minimizing inter-fraction sacral slope variability during radiation therapy

AbstractReproducible patient positioning is essential for precision in radiation therapy (RT) delivery. We tested the hypothesis that a structured daily pre-treatment stretching regimen is both feasible and effective for minimizing variability in positioning, as measured by sacral slope angles (SSA). Eight female subjects undergoing pelvic radiotherapy performed a structured daily hip exercise regimen (extension and external rotation) immediately prior to both simulation imaging and daily treatment, throughout their RT course. This exercising cohort was compared to a retrospective review of 20 subjects (17 women and 3 men) undergoing RT, who had usual care. SSA measurements from daily pre-treatment imaging were compared to SSA measurements from the simulation CT. The average variation in SSA among the intervention subjects was 0.91 ° (± 0.58°), with a range among subjects of 0.57°–1.27°. The average variation for the control subjects was 2.27° (± 1.43°), ranging 1.22°–5.09°. The difference between the two groups was statistically significant (p = 0.0001). There was a statistically significant SSA variation between groups at each week of treatment. There was no significant variation among the intervention subjects between week 1 and later weeks, whereas subjects in the control group demonstrated significant SSA variation between week 1 and later weeks. We demonstrated a significant decrease i...
Source: Medical Oncology - Category: Cancer & Oncology Source Type: research

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CONCLUSION: This study found that childhood cancer survivors in New Zealand had a high prevalence of developmental dental abnormalities and it identified potential risk factors related to their cancer treatment. Inequitable access to oral rehabilitation for this patient group argues for a mechanism for consistent improved access to publicly funded dental care across district health boards in New Zealand. PMID: 33032302 [PubMed - in process]
Source: New Zealand Medical Journal - Category: General Medicine Tags: N Z Med J Source Type: research
AbstractAbstractCancer patients with acute coronary syndrome (ACS) have significantly greater mortality compared with non-cancer patients. This risk is partly directly attributable to the malignancy; however these patients are frequently undertreated with respect to guideline recommended treatments for ACS due to higher bleeding risks from anemia and thrombocytopenia. Due to exclusion from large clinical trials, there is a paucity of data regarding how to best treat these complex and high-risk patients.Purpose of ReviewTo review the literature and identify risk factors among cancer patients associated with poor outcomes, p...
Source: Current Cardiology Reports - Category: Cardiology Source Type: research
Conclusions Amifostine resulted in a significant improvement in type I collagen fibril organization and collagen synthesis, whereas DFO mitigated abnormal changes in collagen secondary structure in an irradiated murine model of expander-based breast reconstruction. These therapeutics offer the ability to retain the native microarchitecture of type I collagen after radiation. Amifostine and DFO may offer clinical utility to reduce radiation induced dermal injury, potentially decreasing the high complication rate of expander-based breast reconstruction with adjuvant XRT and improving surgical outcomes.
Source: Annals of Plastic Surgery - Category: Cosmetic Surgery Tags: Research Source Type: research
Publication date: Available online 9 September 2020Source: Practical Radiation OncologyAuthor(s): Hui Zhao, Adam Paxton, Vikren Sarkar, Y. Jessica Huang, Fan-Chi Frances Su, Christine Haacke, Prema Rassiah-Szegedi, Martin Szegedi, Bill Salter
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
ConclusionViscum pleurodesis showed comparable treatment results with talc pleurodesis while its adverse effects such as chest pain and fever tended to be relatively weak.
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research
The American Society of Radiologic Technologists (ASRT) Foundation and radiation...Read more on AuntMinnie.comRelated Reading: ASRT, Canon announce Safety First winners ASRT Foundation awards more than $200K in scholarships ASRT endows $25K to cardiovascular imaging research Elekta gets FDA nod for DWI-MR radiation therapy ViewRay inks deal with Elekta, Medtronic Elekta secures 5-year Premier contract
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Condition:   Melanoma Interventions:   Biological: Nivolumab;   Biological: Pembrolizumab;   Radiation: Radiation Therapy;   Biological: Therapeutic Exchange Plasma Sponsors:   Mayo Clinic;   National Cancer Institute (NCI) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Renal Cell Carcinoma;   Stage I Renal Cell Cancer AJCC v8;   Stage II Renal Cell Cancer AJCC v8 Interventions:   Procedure: Magnetic Resonance Imaging;   Other: Questionnaire Administration;   Radiation: Stereotactic Body Radiation Therapy Sponsors:   M.D. Anderson Cancer Center;   National Cancer Institute (NCI) Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusions: Lung CT imaging combined with clinical and laboratory findings can facilitate early diagnosis and appropriate management of COVID-19 pneumonia with a history of malignancy and radiation therapy. PMID: 33029098 [PubMed - in process]
Source: International Journal of Medical Sciences - Category: Biomedical Science Tags: Int J Med Sci Source Type: research
Condition:   Melanoma Interventions:   Biological: Nivolumab;   Biological: Pembrolizumab;   Radiation: Radiation Therapy;   Biological: Therapeutic Exchange Plasma Sponsors:   Mayo Clinic;   National Cancer Institute (NCI) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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