Differential Responses of Human Dendritic Cells to Live or Inactivated Staphylococcus aureus: Impact on Cytokine Production and T Helper Expansion

This study underscores the capacity of human DC to discriminate between live and inactivated S. aureus and, further, indicates that DC may represent a valuable experimental setting to test different inactivation methods with regard to the retention of S. aureus immunoregulatory properties. These and further insights may be useful for the development of novel therapeutic and prophylactic anti-S. aureus vaccine strategies.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

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Authors: Reissier S, Cattoir V Abstract INTRODUCTION: Streptogramins (pristinamycin and quinupristin-dalfopristin) can be interesting options for the treatment of infections due to Gram-positive cocci, especially multidrug-resistant isolates. AREAS COVERED: This review provides an updated overview on structural and activity characteristics, mechanisms of action and resistance, pharmacokinetic/pharmacodynamic and clinical use of streptogramins. EXPERT OPINION: The streptogramin antibiotics act by inhibition of the bacterial protein synthesis. They are composed of two chemically distinct compounds, namely typ...
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research
Emergency-use authorizations, a formerly obscure corner of regulatory law, have become a centerpiece of the government ’s response to the pandemic.
Source: NYT - Category: American Health Authors: Tags: your-feed-science Coronavirus Risks and Safety Concerns Food and Drug Administration Hahn, Stephen M (1960- ) Coronavirus (2019-nCoV) Vaccination and Immunization Clinical Trials Drugs (Pharmaceuticals) your-feed-health your-feed-healthc Source Type: news
The use of an immune-system stimulant harvested from shark liver oil in the development of some coronavirus vaccines has animal conservationists pressing for alternatives.(Image credit: Reinhard Dirscherl/ullstein bild via Getty Images)
Source: NPR Health and Science - Category: Consumer Health News Authors: Source Type: news
Authors: Abdeta D, Kebede N, Giday M, Terefe G, Abay SM Abstract Microbial resistance to the few conventional antitrypanosomal drugs, increasing resistance of vectors to insecticides, lack of effective vaccines, and adverse effects of the existing antitrypanosomal drugs justify the urgent need for effective, tolerable, and affordable drugs. We assessed antitrypanosomal effects of the hydromethanolic extract of Echinops kebericho Mesfin roots against Trypanosoma congolense field isolate using in vitro and in vivo techniques. Parasite load, packed cell volume (PCV), body weight, and rectal temperature in Swiss albino...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Phoenix Children ’s Hospital held its fourth annual flu POD (point of distribution) this week, with this year's 13-hour blitz holding a special significance amid the global Covid-19 pandemic. On Oct. 7, nurses began vaccinating employees at 6 a.m. and concluded the one-day event at 7 p.m., vaccinating nearly 5,00 0 people. It’s preparation for another potential mass vaccination event: distribution of a safe and effective vaccine for Covid-19. Click through the photo gallery above to see scenes…
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
This study investigated antibacterial-producing Streptomyces isolated from the gut of estuarine fish Chanos chanos, emphasizing screening for the producer of peptide-containing antibacterial compounds. Eighteen isolates were found during preliminary screening, in which four isolates showed the best antibacterial activities. Based on the morphological, physiological, and biochemical characterization, as well as 16S rRNA partial sequencing, all of the four isolates belonged to Streptomyces. Three isolates were suspected as novel isolate candidates based on homology presentations and phylogenetic tree analysis. Disk-diffusion...
Source: International Journal of Microbiology - Category: Microbiology Tags: Int J Microbiol Source Type: research
Publication date: Available online 9 October 2020Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Cezhi Du, Chengyong Wang, Jianbo Sui, Lijuan Zheng
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Phoenix Children ’s Hospital held its fourth annual flu POD (point of distribution) this week, with this year's 13-hour blitz holding a special significance amid the global Covid-19 pandemic. On Oct. 7, nurses began vaccinating employees at 6 a.m. and concluded the one-day event at 7 p.m., vaccinating nearly 5,00 0 people. It’s preparation for another potential mass vaccination event: distribution of a safe and effective vaccine for Covid-19. Click through the photo gallery above to see scenes…
Source: bizjournals.com Health Care News Headlines - Category: Health Management Authors: Source Type: news
CONCLUSION: There is a high prevalence of MRSA causing abscesses in the Hispanic population evaluated in an ED in Puerto Rico. Systemic antibiotic use for the treatment of skin abscesses after incision and drainage remains high despite published guidelines arguing against their widespread use. Clindamycin resistance in our patient population appears to be more frequent than previously reported. PMID: 33031694 [PubMed - as supplied by publisher]
Source: Puerto Rico Health Sciences Journal - Category: International Medicine & Public Health Tags: P R Health Sci J Source Type: research
Publication date: December 2020Source: Microbial Pathogenesis, Volume 149Author(s): Cemile Selin Aksoy, Fatma Gizem Avci, Osman Mutluhan Ugurel, Basak Atas, Nihat Alpagu Sayar, Berna Sariyar Akbulut
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
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