Facile and Efficient Synthesis of New Class of Imidazole Derivatives via one-pot Multicomponent Reactions in Water.

Facile and Efficient Synthesis of New Class of Imidazole Derivatives via one-pot Multicomponent Reactions in Water.
Comb Chem High Throughput Screen. 2013 Jul 8;
Authors: Hossaini Z, Seyfi S, Rostami-Charati F, Ghambarian M
Abstract
A water-accelerated multicomponent synthesis of organic target molecules has been used as a key method for the preparation of novel imidazole derivatives. The three-component condensation reactions of primary amines with trichloroacetonitrile in the presence of ninhydrine in water are developed as efficient and clean green synthetic procedures for the high-yielding preparation of imidazoles.
PMID: 23848311 [PubMed - as supplied by publisher]

Source: Combinatorial Chemistry and High Throughput Screening - July 8, 2013 Category: Chemistry Authors: Hossaini Z, Seyfi S, Rostami-Charati F, Ghambarian M Tags: Comb Chem High Throughput Screen Source Type: research