Case of the Week 568

This week's case is from Old One - illustrated by him and animated by his son. It features an arthropod that measures a few millimeters in length.See it in actionHERE!Identification?
Source: Creepy Dreadful Wonderful Parasites - Category: Parasitology Source Type: blogs

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Mucosal leishmaniosis (ML) is a chronic infection that affects the upper respiratory tract or oral mucosa, caused by Leishmania protozoan parasites. Four male patients between the ages of 60 and 94 years presented with oral lesions of ML. All of them presented with destruction of the nasal septum and infiltrative lesions in the soft palate, with a granulomatous and erythematous base. One of the patients presented with edema and erythema in the nose and middle face. The histopathologic exam was performed in all the cases, but, polymerase chain reaction (PCR) was necessary in 2 cases to confirm the diagnosis.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Source Type: research
In this study, SS attached to plant bodies were subjected to acid and heat treatments, followed by grinding, to obtain 10–40-nm siliceous sponge spicules (SSS). SSS and polylactic acid (PLA) were then combined to create 50–450-nm PLA/SSS composite nanofibers. The morphology and bioactivity of the electrospun PLA/SSS nanofibers were examined; the tensile, thermal, and water-resistant properties of the fibers were also evaluated. Our results showed a dramatic enhancement in the thermal and tensile properties of PLA with increasing SSS content; specifically, a 3 wt% increase in SSS content resulted in a 47&nb...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Abstract Given that the C580Y polymorphism in the Plasmodium falciparum propeller domain of the kelch 13 gene (pfk13) was documented in Guyana, monitoring for mutations associated with antimalarial resistance was undertaken in neighboring Roraima state in Brazil. Polymorphisms in the pfmdr1 and pfk13 genes were investigated in 275 P. falciparum samples. No pfk13 mutations were observed. Triple mutants 184F, 1042D, and 1246Y were observed in 100% of the samples successfully sequenced for the pfmdr1 gene, with 20.1% of these having an additional mutation at codon 1034C. Among them, 2.5% of samples harbored two copie...
Source: The American Journal of Tropical Medicine and Hygiene - Category: Tropical Medicine Authors: Tags: Am J Trop Med Hyg Source Type: research
Publication date: Available online 13 December 2019Source: Veterinary ParasitologyAuthor(s): Mohamed Abdo Rizk, Shimaa Abd El-Salam El-Sayed, Medhat Nassif, Juan Mosqueda, Xuenan Xuan, Ikuo IgarashiAbstractAbsence of an effective high-throughput drug-screening system for Babesia parasites is considered one of the main causes for the presence of a wide gap in the treatment of animal babesiosis when compared with other hemoprotozoan diseases, such as malaria. Recently, a simple, accurate, and automatic fluorescence assay was established for large-scale anti-Babesia (B. bovis, B. bigemina, B. divergens, B. caballi and T. equi...
Source: Veterinary Parasitology - Category: Veterinary Research Source Type: research
Publication date: Available online 14 December 2019Source: Biological ControlAuthor(s): Wei Zhang, Dandan Liu, Zhichao Yu, Bin Hou, Yaru Fan, Zehao Li, Shijie Shang, Yidan Qiao, Jiangtao Fu, Jiekang Niu, Bin Li, Kexin Duan, Xiaoye Yang, Rui WangAbstractDuddingtonia flagrans is a nematode-trapping fungus that is widely used to control parasitic nematodes in livestock. To investigate the features and advantages of D. flagrans for nematode control at the molecular level, the genome and transcriptome of D. flagrans were sequenced and studied through a comparative analysis. The genome of D. flagrans had a size of 36.3 Mb and co...
Source: Biological Control - Category: Biology Source Type: research
In this study, we reported the in vitro schistosomicidal activity of the R. graveolens extract (Rg) and its active fraction (Rg-FAE). Also, the characterization of Rg-FAE by UPLC-ESI-QTOF-MS analysis and its in vitro antileishmanial activity against Leishmania braziliensis were also performed. In vitro schistosomicidal assays were assessed against adult worms of S. mansoni, while cell viability against peritoneal macrophages was measured by MTT assay. Rg (100 μg/mL) exhibited noticeable schistosomicidal activity, causing 100% mortality and decreasing motor activity of all adult male and female schistosomes, but w...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Authors: Idris OA, Wintola OA, Afolayan AJ Abstract Traditional folks in different parts of the world use Rumex crispus L. for the treatment of microbial infections, malaria, and sleeping sickness in the form of decoction or tincture. In the search for a natural alternative remedy, this study aimed to evaluate the antimicrobial, antitrypanosomal, and antiplasmodial efficacy and the toxicity of R. crispus extracts. Antimicrobial potency of the extracts was evaluated using the agar dilution method to determine the minimum inhibitory concentration (MIC). The antitrypanosomal activity of the extracts was evaluated with...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Conclusion: This in vitro study showed that the EETC contains promising phytochemicals effective against T. gondii and safe to the host cells. PMID: 31827548 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Publication date: Available online 12 December 2019Source: Journal of Theoretical BiologyAuthor(s): Alex Blokhuis, Philippe Nghe, Luca Peliti, David LacosteAbstractCan prelife proceed without cell division? A recently proposed mechanism suggests that transient compartmentalization could have preceded cell division in prebiotic scenarios. Here, we study transient compartmentalization dynamics in the presence of mutations and noise in replication, as both can be detrimental the survival of compartments. Our study comprises situations where compartments contain uncoupled autocatalytic reactions feeding on a common resource, a...
Source: Journal of Theoretical Biology - Category: Biology Source Type: research
Abstract An association between malaria and risk for death among patients with Ebola virus disease has suggested within-host interactions between Plasmodium falciparum parasites and Ebola virus. To determine whether such an interaction might also influence the probability of acquiring either infection, we used a large snapshot surveillance study from rural Gabon to test if past exposure to Ebola virus is associated with current infection with Plasmodium spp. during nonepidemic conditions. We found a strong positive association, on population and individual levels, between seropositivity for antibodies against Ebol...
Source: Emerging Infectious Diseases - Category: Infectious Diseases Authors: Tags: Emerg Infect Dis Source Type: research
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