Cerebrospinal fluid and blood lactate concentrations as prognostic biomarkers in dogs with meningoencephalitis of unknown origin

Publication date: Available online 10 November 2019Source: The Veterinary JournalAuthor(s): M. Portero, E. Martínez de Merlo, C. Pérez, M. Benito, M.A. Daza, C. FragioAbstractMeningoencephalitis of unknown origin (MUO) is a common inflammatory disease of the central nervous system. Several studies investigated finding prognostic factors, but results are contradictory. The aim of this study was to determine the concentrations of blood lactate (Blood-L) and cerebrospinal fluid lactate (CSF-L) in dogs with MUO for prognostic purposes. A total of 45 dogs with MUO (MUO group) and 11 with idiopathic epilepsy (IE group) were included. In the MUO group, 22 dogs were treated with prednisolone + cytosine arabinoside, 17 with prednisolone ± cyclosporine, and six received no treatment.In the MUO group, there was a strong-moderate positive correlation between Blood-L and CSF-L (ρ = 0.63557; P 
Source: The Veterinary Journal - Category: Veterinary Research Source Type: research

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Publication date: Available online 11 December 2019Source: Neurochemistry InternationalAuthor(s): Kuo Zhang, Fan Wang, Yang Zhao, Meiyao He, Yuanchao Luo, Yue Cheng, Jing Luo, Zhimei Li, Jingyu YangAbstractAdult hippocampal neurogenesis plays the pivotal roles in central nervous system diseases. Recently, it has been reported that levetiracetam (LEV), a new antiepileptic drug with novel chemical construction and unique pharmacological properties, suppressed aberrant adult subventricular zone (SGZ) neurogenesis in kainite-induced epileptic mice, while promoted adult SGZ neuroblast differentiation in normal mice. These studi...
Source: Neurochemistry International - Category: Neuroscience Source Type: research
Publication date: March 2020Source: Biomedical Signal Processing and Control, Volume 57Author(s): Susanta Kumar Rout, Pradyut Kumar BiswalAbstractIn this paper, variational mode decomposition (VMD), Hilbert transform (HT), and proposed error-minimized random vector functional link network (EMRVFLN) are integrated to detect and classify epileptic seizure from electroencephalogram (EEG) signals. VMD is applied to decompose the EEG signal into Band-limited intrinsic mode functions (BLIMFs). The five efficacious instantaneous features are computed using HT to construct the feature vector. Proposed EMRVFLN classifier is used to...
Source: Biomedical Signal Processing and Control - Category: Biomedical Science Source Type: research
Authors: Kavčič A, Kajdič N, Rener-Primec Z, Krajnc N, Žgur T Abstract To review the outcome of vagus nerve stimulation (VNS) therapy in all implanted Slovenian patients with drug-resistant epilepsy, data on 48 patients implanted between 2001 and 2015 were obtained retrospectively from medical records. The outcome was assessed in 2016. Out of 48 patients, 39 responded at follow up. The seizure frequency was reduced in 18 (46.2%) patients; 13 (33.3%) of them reported ≥50% reduction after 12 months of therapy. The responder rate was higher among patients implanted before the age of six years. Ictal severity de...
Source: Acta Clinica Croatica - Category: General Medicine Tags: Acta Clin Croat Source Type: research
Marinus Pharmaceuticals Inc. expects to bring in $65 million this week from a public stock offering and concurrent private placement. The proceeds from the stock sales will be used by the Radnor company to advance the preclinical and clinical development of ganaxolone, its lead new drug candidate. Marinus is developing ganaxolone as a potential treatment for epilepsy, depression and other neuropsychiatric disorders. The funds wi ll be used for clinical trial expenses related to the company's seizure…
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
In the first study of its kind, investigators, using AI, found that young epilepsy patients were more than twice as likely as adults with epilepsy to discuss suicidal thoughts and behaviors online.Medscape Medical News
Source: Medscape Pediatrics Headlines - Category: Pediatrics Tags: Neurology & Neurosurgery News Source Type: news
Publication date: December 2019Source: Seizure, Volume 73Author(s): Sang-Ahm Lee
Source: Seizure - Category: Neurology Source Type: research
Publication date: January 2020Source: Epilepsy &Behavior, Volume 102Author(s): Marilyn Jones-Gotman
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
The objective of this study was to perform a cross-cultural adaption and psychometric evaluation of the Spanish version of the Satisfaction with Epilepsy Care (SEC) questionnaire and analyze patient satisfaction with epilepsy care.MethodsTranscultural adaptation and validation of the SEC were carried out using translation and back-translation with pilot testing and an expert panel. The SEC-E (Spanish) was analyzed in 213 patients with epilepsy to examine construct and criterion validity and internal consistency.ResultsThe SEC-E achieved conceptual, semantic, and content equivalence with the original version. For content va...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Authors: Kurihara M, Ishiura H, Bannai T, Mitsui J, Yoshimura J, Morishita S, Hayashi T, Shimizu J, Toda T, Tsuji S Abstract Heterozygous mutations in KIF1A have been reported to cause syndromic intellectual disability or pure spastic paraplegia. However, their genotype-phenotype correlations have not been fully elucidated. We herein report a man with autism and hyperactivity along with sensory disturbance and spastic paraplegia, carrying a novel de novo mutation in KIF1A (c.37C>T [p.R13C]). Autism and hyperactivity have only previously been reported in a patient with c.38 G>A (R13H) mutation. This case sugge...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Abstract Neurological diseases particularly Alzheimer's disease (AD), Parkinson's disease (PD), stroke, and epilepsy are on the rise all around the world causing morbidity and mortality globally with a common symptom of gradual loss or impairment of motor behaviour. Striatum, which is a component of the basal ganglia, is involved in facilitating voluntary movement while the cerebellum is involved in the maintenance of balance and coordination of voluntary movements. Dopamine, serotonin, gamma-aminobutyric acid (GABA), and glutamate, to name a few, interact in regulating the excitation and inhibition of motor neuro...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
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