Editing the Epigenome to Tackle Brain Disorders.

Editing the Epigenome to Tackle Brain Disorders.
Trends Neurosci. 2019 Nov 07;:
Authors: Liu XS, Jaenisch R
Abstract
Genetic studies of epigenetic modifiers such as DNA methyltransferases and histone acetyltransferases have revealed a critical role for epigenetic regulation during brain development and function. Alteration of epigenetic modifications have been documented in a variety of brain disorders, including neurodevelopmental, psychiatric, and neurodegenerative diseases. Development of epigenome editing tools enables a functional dissection of the link between altered epigenetic changes and disease outcomes. Here, we review the development of epigenome editing tools, summarize proof of concept applications focusing on brain disease-associated genes, and discuss the promising application and challenges of epigenome editing to tackle brain disorders.
PMID: 31706628 [PubMed - as supplied by publisher]

Source: Trends in Neurosciences - November 6, 2019 Category: Neuroscience Authors: Liu XS, Jaenisch R Tags: Trends Neurosci Source Type: research