Genetic Markers in Psychiatry.

Genetic Markers in Psychiatry. Adv Exp Med Biol. 2019;1192:53-93 Authors: Nedic Erjavec G, Svob Strac D, Tudor L, Konjevod M, Sagud M, Pivac N Abstract Psychiatric disorders such as addiction (substance use and addictive disorders), depression, eating disorders, schizophrenia, and post-traumatic stress disorder (PTSD) are severe, complex, multifactorial mental disorders that carry a high social impact, enormous public health costs, and various comorbidities as well as premature morbidity. Their neurobiological foundation is still not clear. Therefore, it is difficult to uncover new set of genes and possible genetic markers of these disorders since the understanding of the molecular imbalance leading to these disorders is not complete. The integrative approach is needed which will combine genomics and epigenomics; evaluate epigenetic influence on genes and their influence on neuropeptides, neurotransmitters, and hormones; examine gene × gene and gene × environment interplay; and identify abnormalities contributing to development of these disorders. Therefore, novel genetic approaches based on systems biology focused on improvement of the identification of the biological underpinnings might offer genetic markers of addiction, depression, eating disorders, schizophrenia, and PTSD. These markers might be used for early prediction, detection of the risk to develop these disorders, novel subtypes of the diseases and tailored, personalized approach t...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research

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Authors: Beszłej JA, Wieczorek T, Kobyłko A, Piotrowski P, Siwicki D, Weiser A, Fila-Witecka K, Rymaszewska J, Tabakow P Abstract Deep brain stimulation (DBS) is a treatment method that is currently getting more and more attention from psychiatrists. It has proven to be efficacious and safe in the treatment of neurological disorders, mainly Parkinson's disease (PD), dystonia and essential tremor. DBS has very often contributed to successful treatment in cases that had proved resistant to all other methods of treatment. Nowadays treatment-resistant obsessive-compulsive disorder (OCD) is the main psychiatric indica...
Source: Psychiatria Polska - Category: Psychiatry Tags: Psychiatr Pol Source Type: research
After repeated exposure to a piece of information, people will start assuming it’s true, whether or not it actually is, simply because they’ve heard it so many times. Familiarity and repetition can overcome rationality, a phenomenon psychologists call the “illusory truth effect.” In a 24-hour period during the first weekend of August, two mass shootings—one in El Paso, Texas and the other in Dayton, Ohio—left 31 people dead and 53 injured, as of writing. In between “calls for action” and the need for “thoughts and prayers,” legislators across the political spectru...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized health Source Type: news
Police officers are often the first responders when someone is having a mental illness crisis.  But are members of law enforcement properly equipped for this job?  There are plenty of horrifying stories that would indicate that the answer is “no.”  How do we change this?  Join us as Gabe speaks with Officer Rebecca Skillern from the Huston, Texas, Police Department about how Houston is training its officers to respond to these difficult calls. SUBSCRIBE &REVIEW   Guest information for ‘Policing and Crisis Intervention Training’ Podcast Episode   Officer Rebecca S...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Policy and Advocacy Relationships The Psych Central Show Source Type: blogs
In this paper, we conduct a literature survey about various virtual reality (VR) treatments in psychiatry. We collect 36 studies that made use of VR to provide clinical trials or therapies for patients with psychiatric disorders. In order to gain a better understanding of the management of pain and stress, we first investigate VR applications for patients to alleviate pain and stress during immersive activities in a virtual environment. Particularly for anxiety, VR exposure therapies are effective in provoking realistic reactions to feared stimuli. On top of that, the exposure therapies with simulated images are beneficial...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Marijuana legalization is in motion: step by step, state by state. Counting Washington, where I live, twelve states have already passed recreational marijuana legislation. At least seven more states, including New York and Minnesota, both traditionally liberal states, are slated for similar legalization in 2019.  While stopping the weed train is unlikely (there are profits to be made in this new frontier), ensuring that its brakes and safety protocols are in working order is imperative. Protections for our most vulnerable populations — adolescents, young adults, and people with mental illness issues — ough...
Source: Psych Central - Category: Psychiatry Authors: Tags: Addictions Medications Professional Stigma Substance Abuse Effects Of Cannabis Legalizing Marijuana Psychosis Stigmatization Substance Use THC Source Type: news
What Are 5 Underlying Reasons for Addiction? Addiction always stems from a root cause, also known as one of the reasons for addiction. It is extremely important to treat both the root cause of the addiction in addition to the physical addiction itself. Staying sober involves much more than just detoxing from drugs or alcohol and abstaining from them in the future. It also involves finding the underlying reasons for the addiction and treating that as well, so that it does not exacerbate the addiction in the future. This is why so many people fail when they attempt to quit using drugs or alcohol cold turkey. While there can ...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Abuse Addiction Addiction Recovery Addiction to Pharmaceuticals Addiction Treatment and Program Resources Alcohol Alcoholism Anxiety Children Depression Depression Treatment Drug Treatment LGBT LGBTQ Mental Health Painkiller Source Type: blogs
AbstractExamine the unmet needs of people with serious mental illness (SMI) from the perspective of certified peer specialists. 267 certified peer specialists from 38 states completed an online survey (female [73%], 50.9 [SD = 12] years, and non-Hispanic White [79.8%]). Many respondents reported a primary mental health diagnoses (n = 200), 22 respondents reported their diagnosis as schizophrenia spectrum disorder (11%), 46 respondents reported bipolar disorder (22.1%), 47 respondents reported major depressive disorder (22.6%), 29 respondents reported post-traumatic stress disorder (13.9%), 27 respon...
Source: Psychiatric Quarterly - Category: Psychiatry Source Type: research
Conclusion Currently available pharmacotherapies for PTSD are poorly effective on a substantial proportion of patients. Given this high rate of pharmacological unresponsiveness, further studies are needed to extend the knowledge of the basic mechanisms associated with the pathophysiology of this disorder. The findings discussed in this review suggest that DAergic dysfunction, especially genetic-dependent DAergic alteration, plays a prominent role in the pathophysiology of PTSD; as a consequence, drugs targeting the DAergic system might be therapeutically relevant. A better understanding of how and which DAergic dysfunctio...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Does Prenatal Stress Shape Postnatal Resilience? – An Epigenome-Wide Study on Violence and Mental Health in Humans Fernanda Serpeloni1,2, Karl M. Radtke1,3, Tobias Hecker4, Johanna Sill1, Vanja Vukojevic5, Simone G. de Assis2, Maggie Schauer1, Thomas Elbert1 and Daniel Nätt6* 1Clinical Psychology and Neuropsychology, Department of Psychology, University of Konstanz, Konstanz, Germany 2Department of Studies in Violence and Health Jorge Careli, National School of Public Health of Rio de Janeiro – National Institute of Women, Children and Adolescents Health Fernandes Figueira, Oswaldo Cruz Foundation, ...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Conclusion It is clear that clinically, there is still much to be learnt about alexithymia and its relationship with a range of related phenomena. Firstly, is alexithymia a continuous and stable trait independent of psychological or somatic symptomology that is developed during childhood? Or is it instead a reactive state induced by trauma and distress at any age, which serves to defend against intense and upsetting emotions? This impacts on treatment options. For example, should we be focussing on early childhood interventions which target the child's emotional environment and parenting to encourage emotional exp...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
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