Interventions Addressing the Telomere-Telomerase System.

Interventions Addressing the Telomere-Telomerase System. Adv Exp Med Biol. 2019;1192:521-544 Authors: Muneer A Abstract Major psychiatric disorders are linked to early mortality and patients afflicted with these ailments demonstrate an increased risk of developing physical diseases that are characteristically seen in the elderly. Psychiatric conditions like major depressive disorder, bipolar disorder, and schizophrenia may be associated with accelerated cellular aging, indicated by shortened leukocyte telomere length (LTL), which could underlie this connection. Telomere shortening occurs with repeated cell division and is reflective of a cell's mitotic history. It is also influenced by cumulative exposure to inflammation and oxidative stress as well as the availability of telomerase, the telomere-lengthening enzyme. Precariously short telomeres can cause cells to undergo senescence, apoptosis, or genomic instability; shorter LTL correlates with compromised general health and foretells mortality. Important data specify that LTL may be reduced in principal psychiatric illnesses, possibly in proportion to exposure to the ailment. Telomerase, as measured in peripheral blood monocytes, has been less well characterized in psychiatric illnesses, but a role in mood disorder has been suggested by preclinical and clinical studies. In this manuscript, the most recent studies on LTL and telomerase activity in mood disorders are...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research

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There is no time more joyous and stressful as the end of year holidays. As we fast approach the holidays this year it’s time to start thinking about how you’ll navigate family parties and other familial obligations. In this episode, we give our best tips for making holiday parties less stressful and how to decide if not going is the best option for you.  It’s rough out there, but we care about you and we wish you a happy, healthy holiday season. (Transcript Available Below) SUBSCRIBE &REVIEW About The Not Crazy Podcast Hosts Gabe Howard is an award-winning writer and speaker who lives with bi...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Anxiety and Panic Depression Family General Holiday Coping Not Crazy Podcast Source Type: blogs
Functional coupling of M1 muscarinic acetylcholine receptor to Gαq/11 in dorsolateral prefrontal cortex from patients with psychiatric disorders: a postmortem study. Eur Arch Psychiatry Clin Neurosci. 2019 Dec 05;: Authors: Odagaki Y, Kinoshita M, Meana JJ, Callado LF, García-Sevilla JA Abstract Accumulating studies have implicated intracellular signaling through muscarinic acetylcholine receptors (mAChRs) in psychiatric illness. In the present study, carbamylcholine chloride (carbachol)-induced Gαi/o and Gαq/11 activation was identified in postmortem human prefrontal cortical ...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research
ConclusionsRumination is known to be associated with poor prognosis in mental health. This study suggests that rumination is a maladaptive coping style associated not only with worry, distress and illness severity, but also with socioeconomic status. Also, rumination demonstrated a specific association with panic disorder.
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
Publication date: Available online 7 December 2019Source: Progress in NeurobiologyAuthor(s): M.M.J. van den Berg, J. Krauskopf, J.G. Ramaekers, J.C.S. Kleinjans, J. Prickaerts, J.J. BriedéAbstractCirculating microRNAs (cimiRNAs) are a class of non-encoding RNAs found in bodily fluids such as blood, cerebrospinal fluid (CSF) and tears. CimiRNAs have been implicated as promising biomarkers for central nervous system (CNS) disorders because they are actively secreted as messengers and are profoundly involved in fine-tuning of developmental and differentiation processes. Furthermore, they are attractive biomarkers becau...
Source: Progress in Neurobiology - Category: Neuroscience Source Type: research
AbstractMajor psychiatric traits are genetically inter-correlated with one another, but it not well known which genes play pleiotropic effects across different traits. We curated and compared genes identified from large-scale genome-wide association studies for seven psychiatric traits, including depression, bipolar disorder, schizophrenia, autism spectrum disorder, attention-deficit/hyperactivity disorder, anxiety and neuroticism. We then explored biological functions of the top pleiotropic genes. A total of 243 cross-trait genes were identified for the seven traits. Except for autism spectrum disorder, there was signific...
Source: Human Genetics - Category: Genetics & Stem Cells Source Type: research
Almost half (48%) of children and adolescents with a psychotic disorder said they recently had suicidal thoughts or had in the past considered death by suicide when interviewed in the emergency department (ED) using a brief screening questionnaire, according to areport published this week inPsychiatric Services. Most of these youth did not report a chief complaint related to suicidal ideation or behavior when arriving at the ED.Notably, half of the children and adolescents who screened positive for suicide using the Ask Suicide-Screening Questions (ASQ) screen were discharged from the ED, including 44% of those who reporte...
Source: Psychiatr News - Category: Psychiatry Tags: Ask Suicide-Screening Questions Jonathan DeVylder Psychiatric Services psychotic disorders youth Source Type: research
Authors: Pershad Y, Guo M, Altman RB Abstract One in five Americans experience mental illness, and roughly 75% of psychiatric prescriptions do not successfully treat the patient's condition. Extensive evidence implicates genetic factors and signaling disruption in the pathophysiology of these diseases. Changes in transcription often underlie this molecular pathway dysregulation; individual patient transcriptional data can improve the efficacy of diagnosis and treatment. Recent large-scale genomic studies have uncovered shared genetic modules across multiple psychiatric disorders - providing an opportunity for an in...
Source: Pacific Symposium on Biocomputing - Category: Bioinformatics Tags: Pac Symp Biocomput Source Type: research
We all love and look forward to the holidays, but even good things can be stressful.  Listen in as our guest, PsychCentral.com’s founder, Dr. John Grohol, tells us how to avoid overindulging this year, how to handle the extra work burdens of the season, and how to deal with that annoying relative. SUBSCRIBE &REVIEW Guest information for ‘Holiday Coping’ Podcast Episode John M. Grohol, Psy.D. is a pioneer in online mental health and psychology. Recognizing the educational and social potential of the Internet in 1995, Dr. Grohol has transformed the way people could access mental health and psyc...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Family General Holiday Coping Interview LifeHelper Podcast Relationships Stress The Psych Central Show Source Type: blogs
AbstractAccumulating studies have implicated intracellular signaling through muscarinic acetylcholine receptors (mAChRs) in psychiatric illness. In the present study, carbamylcholine chloride (carbachol)-induced G αi/o and G αq/11 activation was identified in postmortem human prefrontal cortical membranes. The following two sample cohorts were used: subjects [1], consisting of 40 controls without neuropsychiatric disorders, and subjects [2], consisting of 20 with bipolar disorder (BP), 20 major depressive disorder (MDD), 20 schizophrenia, and 20 controls, strictly sex- and age-matched. Carbachol-stimulated [35S...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Neuroscience Source Type: research
Am I an Alcoholic? Alcoholism (also known as Alcohol Use Disorder, or AUD) is a chronic, relapsing disease affecting millions of individuals in the United States. According to the 2017 National Survey on Drug Use and Health (NSDUH), 51 percent of the population aged 12 and older reported binge drinking in the past month. More than 14 million individuals aged 12 and older were suffering from alcoholism. And each year, more than 2,200 individuals die due to alcohol poisoning. Many may come to wonder, “Am I an alcoholic?” What Causes Alcoholism? Some individuals are more prone to alcoholism than others. Alcoholism...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Alcohol Alcoholism alcohol abuse alcohol treatment alcohol treatment center alcohol treatment facility alcoholic alcoholic behavior alcoholics Source Type: blogs
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