Allosteric Modulation of Intrinsically Disordered Proteins.

Allosteric Modulation of Intrinsically Disordered Proteins. Adv Exp Med Biol. 2019;1163:335-357 Authors: Rehman AU, Rahman MU, Arshad T, Chen HF Abstract The allosteric property of globular proteins is applauded as their intrinsic ability to regulate distant sites, and this property further plays a critical role in a wide variety of cellular regulatory mechanisms. Recent advancements and studies have revealed the manifestation of allostery in intrinsically disordered proteins or regions as allosteric sites present within or mediated by IDP/IDRs facilitates the signaling interactions for various biological mechanisms which would otherwise be impossible for globular proteins to regulate. This thematic review has highlighted the biological outcomes that can be achieved by the mechanism of allosteric regulation of intrinsically disordered proteins or regions. The similar mechanism has been implemented on Adenovirus 5 early region 1A and tumor apoptosis protein p53 in correspondence with other partners in binary and ternary complexes, which are the subject of the current review. Both these proteins regulate once they bind to their partners, consequently, forming either a binary or a ternary complex. Allosteric regulation by IDPs is currently a subject undergoing intense study, and the ongoing research work will ensure a better understanding of precision and efficiency of cellular regulation by them. Allosteric regulation mechanism can also be researched by int...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research

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Source: FEBS Letters - Category: Biochemistry Authors: Tags: IN A NUTSHELL Source Type: research
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Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
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Source: FEBS Letters - Category: Biochemistry Authors: Tags: REVIEW Source Type: research
Condition:   Hepatitis B Virus (HBV) Interventions:   Biological: ETV/TDF+T101 No.1;   Biological: ETV/TDF+T101 No.2;   Biological: ETV or TDF;   Biological: ETV/TDF+Peg-IFNα-2b Sponsor:   Tasly Tianjin Biopharmaceutical Co., Ltd. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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