FOXM1 drives proximal tubule proliferation during repair from acute ischemic kidney injury

In conclusion, dedifferentiated proximal tubule cells effect proximal tubule repair, and we reveal an EGFR/FOXM1-dependent signaling pathway that drives proliferative repair after injury.
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research

Related Links:

Publication date: March 2020Source: Materials Today Communications, Volume 22Author(s): Muthu Kumaran M., Ramachandra Murthy A., Vishnuvardhan S.AbstractDissimilar metal joints (DMJs) are more common in the coolant systems of most of the engineering applications and are subjected to variety of loadings. To understand the constraint effect of the dissimilar metal welded joints (DMJs), fracture studies have been carried out on dissimilar metal plate (DMP) with center crack made up of ferritic steel (SA 508 Gr.3 Cl.1), austenitic steel (SA312 Type 304LN) and Inconel – 182 alloy (ENiCrFe-3). 2-D and 3-D finite element an...
Source: Materials Today Communications - Category: Materials Science Source Type: research
Publication date: 15 February 2020Source: Materials Letters, Volume 261Author(s): Pengfei Ren, Faming Wang, Tiantian Zhan, Wanjun Hu, Naizhen Zhou, Tianzhu Zhang, Jinhai YeAbstractNano-hydroxyapatite/chitosan/poly(methyl vinyl ether-alt-maleic anhydride) (NHA/CS/P(MVE-alt-MA)) composite was formed through electrostatic interaction. The results of characterization indicated that the nano-hydroxyapatite (NHA) in the composites was uniformly distributed in the polymer matrices (chitosan/poly(methyl vinyl ether-alt-maleic anhydride) (CS/P(MVE-alt-MA)). With the increase of NHA content, the porosity and strength of the composit...
Source: Materials Letters - Category: Materials Science Source Type: research
In conclusion, the thermosensitive hydrogel of CS/1.0 DEX/β-GP loaded UCMSCs was a promising candidate as cell delivery vehicle for cardiac repair to reconstitute damaged myocardium.
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Publication date: Available online 9 December 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Ting Lei, Wanqi Zhang, Hu Qian, Poon Nian Lim, Eng San Thian, Pengfei Lei, Yihe Hu, Zuyong WangAbstractBiomaterials composed of polymers and bioceramics have great prospects to repair large and complicated bone defects. Here, we developed a composite film consisting of poly(∑-caprolactone) (PCL) and silicon-substituted hydroxyapatite (Si-HA) nanoparticles to enhance the osteogenic effects of the scaffold for bone tissue engineering applications. The results showed that the Si-HA nanoparticles obtained an even dist...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Publication date: Available online 9 December 2019Source: Chemical Engineering and Processing - Process IntensificationAuthor(s): Huijie Zheng, Shaoxiong Fan, Wei Liu, Mengdi ZhangAbstractRhamnolipids are widely investigated to control the growth of food pathogenic bacteria as well as repair environmental problems. This work was proposed to in situ recover rhamnolipids from the fermentation medium of Pseudomonas aeruginosa D1 through foam fractionation. The kinetic model of the fermentation process of Pseudomonas aeruginosa was established, solved and tested. The model fitted well with the experimental data. The results sh...
Source: Chemical Engineering and Processing: Process Intensification - Category: Chemistry Source Type: research
We investigated the local immune status and its prognostic value in lung adenocarcinoma. In total, 513 lung adenocarcinoma samples from TCGA and ImmPort databases were collected and analyzed. The R package coxph was employed to mine immune-related genes that were significant prognostic indicators using both univariate and multivariate analyses. The R software package glmnet was then used for Lasso Cox regression analysis, and a prognosis prediction model was constructed for lung adenocarcinoma; clusterProfiler was selected for functional gene annotations and KEGG enrichment analysis. Finally, correlations between the RiskS...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
DNA double-strand breaks (DSBs) are highly deleterious, with a single unrepaired DSB being sufficient to trigger cell death. Compared to healthy cells, cancer cells have a higher DSB burden due to oncogene-induced replication stress and acquired defects in DNA damage response (DDR) mechanisms. Consequently, hyperproliferating cancer cells rely on efficient DSB repair for their survival. Moreover, augmented DSB repair capacity is a major cause of radio- and chemoresistance and, ultimately, cancer recurrence. Although inherited DDR defects can predispose individuals to develop certain cancers, the very same vulnerability may...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
AbstractPurpose of reviewFunctional mitral regurgitation (MR) in setting of cardiomyopathy causes significant morbidity and worsened survival. Surgical therapies have failed to demonstrate significant overall benefit for functional MR. More recently, major trials utilizing transcatheter therapies for functional MR have been completed and offer new avenues for intervention. This review evaluates and compares 2 major recent trials designed to test the benefit of edge-to-edge repair using the MitraClip system for severe functional MR.Recent findingsThe Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy f...
Source: Current Treatment Options in Cardiovascular Medicine - Category: Cardiology Source Type: research
ConclusionCommon Iliac Artery Aneurysms should be considered a differential diagnosis of lower abdominal mass. If presenting in this manner the aneurysm can be of significant size and at high risk of rupture, requiring urgent surgical intervention.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Publication date: Available online 9 December 2019Source: Journal of Functional FoodsAuthor(s): Rosa Anna Milella, Marica Gasparro, Fiammetta Alagna, Maria Francesca Cardone, Silvia Rotunno, Concetta Tiziana Ammollo, Fabrizio Semeraro, Apollonia Tullo, Flaviana Marzano, Domenico Catalano, Donato Antonacci, Mario Colucci, Domenica D'EliaAbstractUsing a transcriptomic approach, we performed a pilot study in healthy subjects to evaluate the changes in gene expression induced by grape consumption. Blood from twenty subjects was collected at baseline (T0), after 21 days of grape-rich diet (T1) and after one-month washout (...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
More News: Biomedical Science | Gastroschisis Repair | Genetics | Urology & Nephrology