New trihydroxybriarane diterpenoids from an octocoral Briareum sp

Publication date: February 2020Source: Phytochemistry Letters, Volume 35Author(s): Chiung-Chin Hu, Nai-Cheng Lin, Bo-Rong Peng, You-Ying Chen, Zhi-Hong Wen, Yu-Chia Chang, Gene-Hsiang Lee, Yang-Chang Wu, Ping-Jyun SungAbstractChemical investigation of the extract from the supercritical CO2 extraction of an octocoral identified as Briareum sp., afforded a known briarane-type diterpenoid, excavatolide B (1), and a pair of new briaranes, briaviolides Y (2) and Z (3). The absolute configuration of 1 was determined by a single-crystal diffraction analysis and the structures of briaranes 2 and 3 were elucidated by using spectroscopic methods. Additionally, anti-inflammatory analysis showed that briarane 3 suppressed the iNOS and COX-2 levels, in LPS-stimulated RAW264.7 cells.Graphical abstract

Source: Phytochemistry Letters - November 12, 2019 Category: Chemistry Source Type: research