Classification, Characterization, and Sub-Grouping of Interstitial Cystitis

AbstractPurpose of ReviewInterstitial cystitis (IC) and IC-related conditions such as painful bladder syndrome (PBS), bladder pain syndrome (BPS), and hypersensitive bladder (HSB) have a similar symptomatic profile but probably different etiologies. A reasonable classification of these diseases/conditions is mandatory for clinical and investigational progress. We reviewed definition of current terminology and recent research evidence regarding IC and related conditions to propose a sensible classification system.Recent FindingsThe condition with Hunner lesions (Hunner type IC: HIC) is obviously distinct from other categories in terms of histopathology, gene expression, and clinical management; HIC is a bladder-centric disease with heavy inflammation, epithelial denudation, and oligoclonal B cell expansion. Presence of glomerulations or mucosal bleeding after distension appears of least clinical significance. Classification should thus clearly differentiate the condition with Hunner lesions from those without Hunner lesions. The term covering patients as a whole should contain IC, since IC is historically a well-known name and used for insurance reimbursement.SummaryThe proposed classification/taxonomy features an umbrella term (IC/BPS) and two sub-groups, HIC (IC/BPS with Hunner lesions) and BPS (IC/BPS without Hunner lesions). IC/BPS is convenient for the initial management of symptomatic patients, and sub-groups can categorize the patients for the specific management. The c...
Source: Current Bladder Dysfunction Reports - Category: Urology & Nephrology Source Type: research

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Abstract Clinical guidelines for interstitial cystitis and hypersensitive bladder have been updated as of 2015. The guidelines define interstitial cystitis by the presence of hypersensitive bladder symptoms (discomfort, pressure or pain in the bladder usually associated with urinary frequency and nocturia) and bladder pathology, after excluding other diseases explaining symptoms. Interstitial cystitis is further classified by bladder pathology; either Hunner type interstitial cystitis with Hunner lesions or non‐Hunner type interstitial cystitis with mucosal bleeding after distension in the absence of Hunner lesions. Hype...
Source: International Journal of Urology - Category: Urology & Nephrology Authors: Tags: Guideline Source Type: research
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Source: International Journal of Urology - Category: Urology & Nephrology Authors: Tags: Review Article Source Type: research
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