Febuxostat is superior to allopurinol in delaying the progression of renal impairment in patients with chronic kidney disease and hyperuricemia

ConclusionsFebuxostat presents a superior effect in delaying renal impairment progression compared with allopurinol in CKD patients complicated with HUA.
Source: International Urology and Nephrology - Category: Urology & Nephrology Source Type: research

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Albuminuria acts as a marker of progressive chronic kidney disease and as an indicator for initiation of hypertension treatment via modulation of the renin-angiotensin-aldosterone system with angiotensin receptor blockers or angiotensin-converting enzyme inhibitors. However, the true significance of albuminuria has yet to be fully defined. Is it merely a marker of underlying pathophysiology, or does it play a causal role in the progression of kidney disease? The answer remains under debate. In this issue of the JCI, Bedin et al. used next-generation sequencing data to identify patients with chronic proteinuria who had bial...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
AbstractObjectiveThe present study was aimed to investigate (1) whether urodynamic factors are responsible for kidney damage in patients with bladder outlet obstruction (BOO) and (2) whether transurethral prostate surgery for BOO can alleviate the damage to the kidneys.MethodsThis prospective observational study involved men aged 50 –80 years. Prostate size and urodynamic test were performed during screening period. Laboratory tests to measure the glomerular filtration rate, the urinary protein to creatinine ratio and dipstick urinalysis were performed before and 6 months after the transurethral prostate su...
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
This study aimed to investigate whether elevated MLR predicts new-onset CKD.MethodsThis study enrolled 14033 consecutively Chinese participants. The primary outcome was the new-onset CKD defined as an estimated glomerular filtration rate
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
This study aimed to investigate whether elevated MLR predicts new-onset CKD. METHODS: This study enrolled 14033 consecutively Chinese participants. The primary outcome was the new-onset CKD defined as an estimated glomerular filtration rate
Source: International Journal of Clinical Chemistry - Category: Chemistry Authors: Tags: Clin Chim Acta Source Type: research
Conditions:   Chronic Kidney Disease Stage 3B;   Chronic Kidney Disease, Stage 4;   Proteinuria Intervention:   Other: whole food, plant-based diet Sponsor:   University of Rochester Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Objective: to study frequency, identify features of CKD in patients with COPD.Material and Methods: examinations of the functional state of kidneys were carried out in 311 COPD patients (GOLD, 2018): group A - 72, B – 159, C – 53, D – 27. The mean age was 64.8±11.2 years, 66% - men. Exclusion criteria: IHD, hypertension II-III degree, diabetes, CHF.Results: according to KDIGO (2012) criteria, CKD was diagnosed in 87 (28%) patients. The average creatinine – 108,9±11,2 mmol/l, creatinine less than 124/133 µmol/l was in one third of patients. There was a significant correlation of s...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Monitoring airway disease Source Type: research
Introduction: Fat tissue produced inflammatory cytokines which have an impact on systemic diseases such as sarcoidosis(S). Treatment with corticosteroids(CS) can worsen metabolic disoders and patients’ life qualityAim: to assess the role of obesity in clinical aspect of SMethods: 142 patients with S were observed at pulmonology depratment Tareev Clinic. BMI was calculated before treatment was start. Patients were divided into 2groups:gr.1-with obesity(BMI≥30kg/m2)(n=84),gr.2-without obesity(n=58). Control group consisted of 35 patients with chonic bronchitis and obesityResults: There was prevelance of middle aged ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research
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