CAR-T Cells for Cancer Treatment: Current Design and Next Frontiers.
CAR-T Cells for Cancer Treatment: Current Design and Next Frontiers.
Methods Mol Biol. 2020;2086:1-10
Authors: Picanço-Castro V, Swiech K, Malmegrim KCR, Covas DT
Abstract
Immunotherapy has been growing in the past decade as a therapeutic alternative for cancer treatment. In this chapter, we deal with CAR-T cells, genetically engineered autologous T cells to express a chimeric receptor specific for an antigen expressed on tumor cell surface. While this type of personalized therapy is revolutionizing cancer treatment, especially B cell malignancies, it has some challenging limitations. Here, we discuss the basic immunological and technological aspects of CAR-T cell therapy, the limitations that have compromised its efficacy and safety, and the current proposed strategies to overcome these limitations, thereby allowing for greater therapeutic application of CAR-T cells.
PMID: 31707664 [PubMed - in process]
Source: Mol Biol Cell - Category: Molecular Biology Authors: Picanço-Castro V, Swiech K, Malmegrim KCR, Covas DT Tags: Methods Mol Biol Source Type: research
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