Approaches of T Cell Activation and Differentiation for CAR-T Cell Therapies.

Approaches of T Cell Activation and Differentiation for CAR-T Cell Therapies. Methods Mol Biol. 2020;2086:203-211 Authors: Schwab RD, Bedoya DM, King TR, Levine BL, Posey AD Abstract Chimeric antigen receptor (CAR) T cell therapies are ex vivo manufactured cellular products that have been useful in the treatment of blood cancers and solid tumors. The quality of the final cellular product is influenced by several amenable factors during the manufacturing process. This review discusses several of the influences on cell product phenotype, including the raw starting material, methods of activation and transduction, and culture supplementation. PMID: 31707678 [PubMed - in process]
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research