Approaches of T Cell Activation and Differentiation for CAR-T Cell Therapies.

Approaches of T Cell Activation and Differentiation for CAR-T Cell Therapies. Methods Mol Biol. 2020;2086:203-211 Authors: Schwab RD, Bedoya DM, King TR, Levine BL, Posey AD Abstract Chimeric antigen receptor (CAR) T cell therapies are ex vivo manufactured cellular products that have been useful in the treatment of blood cancers and solid tumors. The quality of the final cellular product is influenced by several amenable factors during the manufacturing process. This review discusses several of the influences on cell product phenotype, including the raw starting material, methods of activation and transduction, and culture supplementation. PMID: 31707678 [PubMed - in process]
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research

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Publication date: Available online 13 December 2019Source: Academic RadiologyAuthor(s): Farideh Mohtasham, Jamal Rahmani, Yousef Khani, Siamak Sabour
Source: Academic Radiology - Category: Radiology Source Type: research
Authors: Knight O, Carter CR, Loranger B, Rea PM Abstract Pancreatic cancer is a leading cause of cancer related deaths in the UK. However, public knowledge and understanding of the pancreas is generally poor, therefore pancreatic cancer patients often have to contend with understanding large quantities of new information at a pivotal time in their lives.Despite utilisation of digital visualisation techniques in medical education, very rarely are they being used to help clinicians communicate information to their patients. Specifically, there is no literature describing use of an interactive digital application for...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Recent advances in molecular studies, especially genome-wide analyses, have revealed the landscape of genomic alterations present in endometrial carcinomas, and have provided valuable insight into the pathogenesis of this disease. The current challenges are in developing a molecular-morphologic classification system to enhance traditional pathologic diagnosis and in determining the optimal approach to using this new information to guide clinical management. Molecular assays may be particularly beneficial in allowing the earlier detection of endometrial cancer or precursor lesions and in guiding personalized treatment appro...
Source: International Journal of Gynecological Pathology - Category: Pathology Tags: PATHOLOGY OF THE CORPUS: REVIEW ARTICLE Source Type: research
Cowden syndrome (CS) is a multiple hamartoma syndrome associated with the development of various tumors, including endometrial cancer. However, the histology of CS-associated endometrial cancer remains to be fully described. To our knowledge, this is the first report of a patient with CS having endometrial endometrioid carcinoma with ovarian metastasis demonstrating morula-like features. A 31-yr-old, nulliparous, Japanese woman presented with abnormal genital bleeding. Endometrial biopsy revealed endometrioid carcinoma with an extensive morular formation, partially resembling atypical polypoid adenomyoma (APAM). Moreover, ...
Source: International Journal of Gynecological Pathology - Category: Pathology Tags: PATHOLOGY OF THE CORPUS: CASE REPORT Source Type: research
Brain metastasis is a rare and generally late manifestation of an advanced-stage, high-grade serous ovarian carcinoma. Nowadays, the improved control of intra-abdominal disease by surgery and platinum-based chemotherapy results in a longer survival, allowing distant metastasis to implant and grow in the brain parenchyma. Herein, we describe a unique case of a cerebellar metastasis from clear cell ovarian carcinoma that initially presented as a FIGO Stage IC cancer. Surprisingly, 6 mo after surgery, the patient was in good condition with complete disappearance of symptoms and no evidence of recurrence. This relativel...
Source: International Journal of Gynecological Pathology - Category: Pathology Tags: PATHOLOGY OF THE UPPER TRACT: CASE REPORTS Source Type: research
No abstract available
Source: International Journal of Gynecological Pathology - Category: Pathology Tags: ONLINE ARTICLES: LETTERS TO THE EDITOR Source Type: research
FDA officially has a new boss. The U.S. Senate voted 72-18 on Thursday to confirm Stephen Hahn, MD, as the new FDA Commissioner. The news was largely well received by industry advocacy groups like AdvaMed and professional societies like the American Heart Association. “Dr. Hahn is an excellent choice to lead FDA, and we congratulate him on his swift and overwhelming bipartisan confirmation," said AdvaMed CEO Scott Whitaker. "During the confirmation process, Dr. Hahn demonstrated his deep understanding of the agency’s mission to pr...
Source: MDDI - Category: Medical Devices Authors: Tags: Regulatory and Compliance Source Type: news
An artificial intelligence (AI) algorithm's analysis of MRI exams performed...Read more on AuntMinnie.comRelated Reading: SIR: UFE bests myomectomy for fibroid treatment Artificial intelligence for MRI distinguishes uterine cancer from fibroids Study finds low reintervention rate for UAE of fibroids Further intervention rates vary after fibroid removal Online patient info about UAE could be better
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Osaka University Graduate School of Medicine has signed a collaborative research...Read more on AuntMinnie.comRelated Reading: Isotope shows promise in brain cancer treatment New promise for therapeutic radiopharmaceuticals
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
PET/MRI is better than MRI alone for the detection and staging of nodes and...Read more on AuntMinnie.comRelated Reading: Can FDG-PET/MRI replace biopsy in breast cancer cases? PET/MRI sheds light on cerebral vascular risk factors PET/MRI can pinpoint causes of chronic extremity pain SNMMI: FDG-PET/MRI improves pain diagnosis, management PET/MRI offers view to atherosclerotic disease origin
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
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