Exploring DNA binding ability of two novel α-N-heterocyclic thiosemicarbazone palladium(II) complexes.

Exploring DNA binding ability of two novel α-N-heterocyclic thiosemicarbazone palladium(II) complexes. J Inorg Biochem. 2019 Nov 06;203:110875 Authors: Fuentes L, Quiroga AG, Organero JA, Matesanz AI Abstract One mononuclear and another dinuclear Pd(II) complexes bearing a α-N-heterocyclic thiosemicarbazone ligand have been synthesized, fully characterized and studied as biological agents. In both complexes, the palladium center is coordinated to 3,5-diacetyl-1,2,4-triazol bis(N4,N4-dimethylthiosemicarbazone) via three sites (N, N and S). Their binding ability to DNA has been evaluated using spectroscopic and biophysical techniques. Molecular docking and molecular dynamics calculations supports the existence of a minor groove binding mode between the studied compounds and DNA. PMID: 31706223 [PubMed - as supplied by publisher]
Source: Journal of Inorganic Biochemistry - Category: Biochemistry Authors: Tags: J Inorg Biochem Source Type: research

Related Links:

Publication date: June 2020Source: Journal of Bone Oncology, Volume 22Author(s): Michala Skovlund Sørensen
Source: Journal of Bone Oncology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 4 April 2020Source: Journal of Geriatric OncologyAuthor(s): Kelly M. Trevino, Amy Stern, Holly G. Prigerson
Source: Journal of Geriatric Oncology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 4 April 2020Source: Journal of Geriatric OncologyAuthor(s): Isacco Desideri, Carlotta Becherini, Luca Visani, Giulia Stocchi, Erika Scoccimarro, Matteo Mariotti, Viola Salvestrini, Silvia Scoccianti, Daniela Greto, Pierluigi Bonomo, Guido Pecchioli, Lorenzo Bordi, Alessandro Della Puppa, Giulio Francolini, Icro Meattini, Lorenzo Livi
Source: Journal of Geriatric Oncology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 4 April 2020Source: Journal of Geriatric OncologyAuthor(s): Joshua B. Cadwell, Anoushka M. Afonso, Armin Shahrokni
Source: Journal of Geriatric Oncology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 4 April 2020Source: Journal of Geriatric OncologyAuthor(s): Claire A. Surr, Rachael Kelley, Alys W. Griffiths, Laura Ashley, Fiona Cowdell, Ann Henry, Michelle Collinson, Ellen Mason, Amanda J. Farrin
Source: Journal of Geriatric Oncology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 3 April 2020Source: Anaesthesia Critical Care &Pain MedicineAuthor(s): Brajesh Kaushal, Sandeep Chauhan, Rohan Magoon, Nitish Naik, Ambuj Roy
Source: Anaesthesia, Critical Care and Pain Medicine - Category: Anesthesiology Source Type: research
Publication date: Available online 3 April 2020Source: Anaesthesia Critical Care &Pain MedicineAuthor(s): Frederic J. Baud, Vincent Jullien, Philippe-Henri Secrétan, Pascal Houzé, Lionel Lamhaut
Source: Anaesthesia, Critical Care and Pain Medicine - Category: Anesthesiology Source Type: research
Publication date: Available online 3 April 2020Source: Anaesthesia &Intensive Care MedicineAuthor(s): Viyayanand Nadella
Source: Anaesthesia and intensive care medicine - Category: Anesthesiology Source Type: research
Publication date: Available online 12 March 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Karsten Weller, Tamara Donoso, Markus Magerl, Emel Aygören-Pürsün, Petra Staubach, Inmaculada Martinez-Saguer, Tomasz Hawro, Sabine Altrichter, Karoline Krause, Frank Siebenhaar, Martin Metz, Torsten Zuberbier, Denise Freier, Marcus Maurer
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Publication date: Available online 3 April 2020Source: Autoimmunity ReviewsAuthor(s): Dennis McGonagle, Kassem Sharif, Anthony O'Regan, Charlie Bridgewood
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
More News: Biochemistry | Molecular Biology