Organs from patients with hepatitis C could be SAFE

Canadian researchers found giving uninfected recipients a combination of antiviral and cholesterol-lowering drugs prevented them from contracting the virus.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Many RNA viruses create specialized membranes for genome replication by manipulating host lipid metabolism and trafficking, but in most cases, we do not know the molecular mechanisms responsible or how specific lipids may impact the associated membrane and viral process. For example, hepatitis C virus (HCV) causes a specific, large-fold increase in the steady-state abundance of intracellular desmosterol, an immediate precursor of cholesterol, resulting in increased fluidity of the membrane where HCV RNA replication occurs. Here, we establish the mechanism responsible for HCV's effect on intracellular desmosterol, whereby t...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Microbiology Source Type: research
Authors: Sangineto M, Luglio CV, Mastrofilippo T, Zingaro MT, Berardi E, Antonica G, Sabbà C, Napoli N Abstract INTRODUCTION AND OBJECTIVES: Despite chronic hepatitis C (CHC) is still a global burden as the high morbidity and mortality, the recently approved direct-acting antivirals (DAAs) permit a very high rate of sustained virologic response (SVR) in these patients. The clinical improvement due to viral eradication is being documented, however it is not clear why a subset of patients does not benefit in terms of fibrosis regression or hepatocellular carcinoma (HCC) development. Aim of the study was to ass...
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
AbstractObjectivesTo assess the safety and therapeutic effects of allogeneic human dental pulp stem cells (DPSCs) in treating severe pneumonia caused by COVID-19.Trial designThis is a single centre, two arm ratio 1:1, triple blinded, randomized, placebo-controlled, parallel group, clinical trial.ParticipantsTwenty serious COVID-19 cases will be enrolled in the trial from April 6th to December 31st 2020. Inclusion Criteria: hospitalised patients at Renmin Hospital of Wuhan University satisfy all criteria as below:Adults aged 18-65 years;Voluntarily participate in this clinical trial and sign the “informed consent form...
Source: Trials - Category: Research Source Type: clinical trials
The medical diagnostics industry has been moving steadily from centralized testing toward a decentralized model that brings testing ever closer to the patient. The benefits of point-of-care (POC) interventions are significant, and new technologies have expanded the options of home testing, while new generations of testing kits offer enhanced accuracy, reliability, and speed. Detection and monitoring are especially critical for diseases such as HIV, Hepatitis C (HVC), and colon cancer, and POC technologies can encourage early detection and better testing compliance as they are more accessible for patients. They are also les...
Source: MDDI - Category: Medical Devices Authors: Tags: IVD Source Type: news
Altıntaş E Abstract BACKGROUND/AIMS: In previous studies that investigated the impact of direct-acting antiviral (DAA) treatment on lipid metabolism and insulin resistance in chronic hepatitis C patients have been compared to baseline values with either end of treatment or post-treatment values. The results are inconsistent. We evaluated patients throughout the treatment and after treatment. MATERIALS AND METHODS: 121 patients were included in the study. 93 patients were treated with sofosbuvir/ledipasvir±Ribavirin (RBV), and 28 patients were treated with ombitasvir/paritaprevir/ritonavir+dasabuvir&...
Source: The Turkish Journal of Gastroenterology - Category: Gastroenterology Authors: Tags: Turk J Gastroenterol Source Type: research
As of April 9, PubMed listed 2,868 scientific publications which incorporate the word “COVID”.   323 of these (11.3%) were related to drugs under study for treatment of the disease. No fewer than thirty-one such drugs had been proposed since this pandemic first appeared on the planet four months earlier.    Graph 1 depicts the cumulative numbers of COVID-19 infection (per 100,000 global population) and introductions of relevant drugs into the Literature during February 14 to April 3. Note that both increased by a factor of approximately 16-fold during this perio...
Source: GIDEON blog - Category: Databases & Libraries Authors: Tags: Epidemiology Graphs Source Type: blogs
Publication date: Available online 10 April 2020Source: Journal of the Formosan Medical AssociationAuthor(s): Ching-Sheng Hsu, Wei-Liang Liu, Qisheng Li, Brianna Lowey, Laura Hertz, You-Chen Chao, T. Jake Liang, Ding-Shinn Chen, Jia-Horng Kao
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research
CONCLUSION: Although HCV infection regulates host lipid metabolism in a genotype-specific manner, its inhibition on hepatocellular cholesterogenic gene expression and total cholesterol biosynthesis is a common effect among HCV genotype 1b, 2a and 3a. PMID: 32284164 [PubMed - as supplied by publisher]
Source: J Formos Med Assoc - Category: General Medicine Authors: Tags: J Formos Med Assoc Source Type: research
Statin may confer anticancer effect. However, the association between statin and risk of hepatocellular carcinoma (HCC) in patients with hepatitis B virus (HBV) or hepatitis C (HCV) virus infection remains inc...
Source: BMC Gastroenterology - Category: Gastroenterology Authors: Tags: Research article Source Type: research
ConclusionsStatin initiators had a lower risk of any ALI outcome compared with non-users within 18  months regardless of HIV and/or HCV status.
Source: American Journal of Cardiovascular Drugs - Category: Cardiology Source Type: research
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