Early risk stratification for diffuse large B-cell lymphoma integrating interim Deauville score and International Prognostic Index

AbstractThe aim of this study was to evaluate the prognostic relevance of early risk stratification in diffuse large B-cell lymphoma (DLBCL) using interim Deauville score on positron emission tomography-computed tomography (PET-CT) scan and baseline International Prognostic Index (IPI). This retrospective study included 220 patients (median age, 64 years; men, 60%) diagnosed with DLBCL between 2007 and 2016 at our institution, treated with rituximab-based chemotherapy. Interim PET-CT was performed after three cycles of immuno-chemotherapy. Interim Deauville score was assessed as 4 or 5 in 49 patients (22.3%), and 94 patients (42.7%) had high-intermediate or high-risk IPI scores. In multivariate analysis, interim Deauville score (1 –3 and 4–5) and baseline IPI (low/low-intermediate and high-intermediate/high) were independently associated with progression-free survival (for Deauville score, hazard ratio [HR], 1.00vs. 2.96 [95% confidence interval (CI), 1.83 –4.78],P< 0.001; for IPI, HR, 1.00vs. 4.84 [95% CI, 2.84 –8.24],P< 0.001). We stratified patients into three groups: low-risk (interim Deauville scores 1 –3 and low/low-intermediate IPI), intermediate-risk (Deauville scores 1–3 with high-intermediate/high IPI or Deauville scores 4–5 with low/low-intermediate IPI), and high-risk (Deauville scores 4–5 and high-intermediate/high IPI). This early risk stratification showed a strong association wi th progression-free survival (HR, 1.00vs. 3.98 [95% CI 2.10 ...
Source: Annals of Hematology - Category: Hematology Source Type: research