Neuroprotection of miR-214 against isoflurane-induced neurotoxicity involves the PTEN/PI3K/Akt pathway in human neuroblastoma cell line SH-SY5Y.

In conclusion, miR-214 protected against isoflurane-induced neurotoxicity in SH-SY5Y cells via regulation of PI3K/Akt pathway by targeting PTEN, contributing to better understanding the underlying mechanisms of anesthetics-induce neurotoxicity. PMID: 31704096 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31704096?dopt=Abstract

Source: Archives of Biochemistry and Biophysics - November 4, 2019 Category: Biochemistry Authors: Wu Q, Shang Y, Shen T, Liu F, Xu Y, Wang H Tags: Arch Biochem Biophys Source Type: research