Bionic pancreas may help control blood sugar levels

According to study published in theJournal of Cystic Fibrosis, a bionic pancreas with a glucose monitoring system, linked to a smart phone app, may help control blood sugar levels in cystic fibrosis-related diabetes.Speciality Medical Dialogues
Source: Society for Endocrinology - Category: Endocrinology Source Type: news

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Cystic fibrosis (CF) disease, which is caused by mutations of the CF transmembrane conductance regulator (CFTR) gene, is characterized by multiorgan deficiencies that begin early in life [1,2]. With the increasing life expectancy due to improvements in the treatment of the disease's pulmonary and gastrointestinal disorders, other CF complications and comorbidities have become more prevalent, such as diabetes and CF-related bone disease (CFBD) with 55 –65% of affected patients being older than 45 [3–5].
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Tags: Original Article Source Type: research
Diabetes is a common complication of cystic fibrosis (CF) that affects approximately 20% of adolescents and 40%–50% of adults with CF. The age at onset of CF-related diabetes (CFRD) (marked by clinical diagnosis and treatment initiation) is an important measure of the disease process. DNA variants associated with age at onset of CFRD reside in and near SLC26A9. Deep sequencing of the SLC26A9 gene in 762 individuals with CF revealed that 2 common DNA haplotypes formed by the risk variants account for the association with diabetes. Single-cell RNA sequencing (scRNA-Seq) indicated that SLC26A9 is predominantly expressed...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Introduction: Identification of risk factors that predict poor survival can aid clinical decision making and allow optimization of any potentially modifiable factors (Stephenson, A.L. et al. J Heart Lung Transplant 2015;34:1139–1145). This may facilitate improved patient selection and ultimately improve overall outcomes.Aims: To describe the Irish experience of co-morbidity post-transplant for cystic fibrosis and to investigate potential non-pulmonary pre-transplant risk factors that could impact on long term survival.Methods: We performed a retrospective review of all 61 patients who received a lung transplant for c...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Transplantation Source Type: research
Bronchiectasis can have different causes. Etiology impact on clinical and functional aspects is little known.Objectives: Identify causes of bronchiectasis non cystic fibrosis(BNFC) and investigate if there are differences concerning clinical, functional and of quality of life(QoL) among groups.Methods: Descriptive and cross-sectional study conducted in a Brazilian University hospital. Patients (N=109, mean age 53 yrs, 60% women) with tomographic diagnosis of bronchiectasis had medical files reviewed and were interviewed to identify personal and familial antecedents; they also performed spirometry and answered the Saint Geo...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Monitoring airway disease Source Type: research
Conclusions: There might be an effect of CFTR-modulators on fecundity and the course and outcome of pregnancy in CF-patients. More data are needed to support the safety or risk for infants of mothers treated with CFTR-modulators.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Cystic fibrosis Source Type: research
Dietary intervention in cystic fibrosis (CF) has historically focused on high-energy diets to address malnutrition, with little attention on diet quality. With increased survival, CF complications such as impaired glucose tolerance (IGT) and cystic fibrosis related diabetes (CFRD) have increased in prevalence. In the absence of consensus on the management of IGT, the role of dietary intake, specifically carbohydrate quality, requires consideration.
Source: Clinical Nutrition - Category: Nutrition Authors: Tags: Original article Source Type: research
Semin Respir Crit Care Med DOI: 10.1055/s-0039-1697917Cystic fibrosis (CF) is one of the most common life-limiting genetic disorders. Although CF is typically considered primarily as a pulmonary disease, the CF conductance transmembrane regulator is present throughout the body. From an endocrine perspective, this multisystem disease manifests primarily in the pancreas as a unique form of diabetes (CF-related diabetes mellitus), as bone disease, and as reproductive health issues in people with CF. These complications have become ever more concerning to people with CF as treatment for pulmonary disease improves and lifespans...
Source: Seminars in Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Review Article Source Type: research
Abstract Cystic fibrosis (CF) is one of the most common life-limiting genetic disorders. Although CF is typically considered primarily as a pulmonary disease, the CF conductance transmembrane regulator is present throughout the body. From an endocrine perspective, this multisystem disease manifests primarily in the pancreas as a unique form of diabetes (CF-related diabetes mellitus), as bone disease, and as reproductive health issues in people with CF. These complications have become ever more concerning to people with CF as treatment for pulmonary disease improves and lifespans lengthen, increasing the impact of ...
Source: Respiratory Care - Category: Respiratory Medicine Authors: Tags: Semin Respir Crit Care Med Source Type: research
The primary cause of mortality in cystic fibrosis (CF) is respiratory failure, however, the increasing survival age means that non-respiratory consequences have a greater bearing upon quality and longevity of life [1]. For example, approximately 35% of adults with CF develop CF-related diabetes (CFRD) [1]. CFRD is associated with a greater decline in lung function [2], worsened nutritional status [3] and poorer prognosis [4]. Cardiopulmonary exercise testing (CPET) is advocated by both the European CF Society and European Respiratory Society [5,6] as a routine clinical assessment.
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Tags: Original Article Source Type: research
Cystic fibrosis related diabetes (CFRD) remains a frequent extra-pulmonary complication of cystic fibrosis (CF) – adding considerably to the treatment burden [1,2]. CFRD is primarily caused by insulin deficiency based on destruction of islet cells in the pancreas, although recent research suggests that CFTR in itself interferes with insulin secretion and glycaemic control [3,4]. Glucose metabolism impairmen t in CF starts from early infancy and continues during life with variable progression, primarily in pancreatic insufficient patients [5–7].
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Tags: Original Article Source Type: research
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