Bionic pancreas may help control blood sugar levels

According to study published in theJournal of Cystic Fibrosis, a bionic pancreas with a glucose monitoring system, linked to a smart phone app, may help control blood sugar levels in cystic fibrosis-related diabetes.Speciality Medical Dialogues
Source: Society for Endocrinology - Category: Endocrinology Source Type: news

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In silico prediction and validation of potential therapeutic genes in pancreatic β-cells associated with type 2 diabetes. Exp Ther Med. 2020 Nov;20(5):60 Authors: Zhou DY, Mou X, Liu K, Liu WH, Xu YQ, Zhou D Abstract Diabetes mellitus is becoming a major health burden worldwide. Pancreatic β-cell death is a characteristic of type 2 diabetes (T2D), but the underlying mechanisms of pancreatic β-cell death remain unknown. Therefore, the aim of the present study was to identify potential targets in the pancreatic islet of T2D. The GSE20966 dataset was obtained from the Gene Expression Omnibu...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Presentation of CF, airway clearance regimens, diabetes in CF, and other highlights from the cystic fibrosis episode of The Cribsiders podcast.Medscape Pediatrics
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Pediatrics Commentary Source Type: news
Alternate methods for characterizing oral glucose tolerance tests (OGTT) have emerged as superior to the 2-hour glucose in identifying individuals at risk for type 2 diabetes. The significance of these methods in cystic fibrosis (CF) is unclear. We compared 3 OGTT classifications in youth with CF: 1. curve shape (biphasic vs. monophasic), 2. time to glucose peak ( ≤30minutes vs.>30minutes), 3. 1-hour glucose (1hG)
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Tags: Original Article Source Type: research
A 15-year old boy with cystic fibrosis-related diabetes (CFRD) presented to the emergency department of his regional hospital with a short history of lethargy, nausea and vomiting, and was found to be markedly hyperglycaemic and hyperosmolar without ketosis.
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Source Type: research
Purpose of review The pancreas is highly affected in cystic fibrosis, with complications occurring early in childhood. This review highlights recent research in exocrine pancreatic function in the era of cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapies and discusses how these are affecting pancreatitis and exocrine pancreatic insufficiency (EPI) in children. Additionally, new research into exocrine--endocrine interactions sheds light on how CFTR dysfunction in ductal cells may affect beta cells. Recent findings Ivacaftor has disproved the hypothesis that EPI in children with cystic fibros...
Source: Current Opinion in Pediatrics - Category: Pediatrics Tags: GASTROENTEROLOGY AND NUTRITION: Edited by Bradley Barth Source Type: research
There is growing evidence that individuals with serious, chronic conditions are at higher risk for symptoms of depression and anxiety. In two recent systematic reviews of psychological distress in individuals with inflammatory bowel disease (IBD) and Type I diabetes, elevated rates of depressive and anxious symptoms were reported by a large percentage of the population. For those with IBD, approximately 22% had elevated symptoms of depression and 35% reported elevated symptoms of anxiety [1]. These rates are similar to those reported by individuals with Type I diabetes, with 30% screening elevated on depression and 32% scr...
Source: Respiratory Medicine - Category: Respiratory Medicine Authors: Tags: Clinical Trial Paper Source Type: research
AbstractThe islets of Langerhans are well embedded within the exocrine pancreas (the latter comprised of ducts and acini), but the nature of interactions between these pancreatic compartments and their role in determining normal islet function and survival are poorly understood. However, these interactions appear to be critical, as when pancreatic exocrine disease occurs, islet function and insulin secretion frequently decline to the point that diabetes ensues, termed pancreatogenic diabetes. The most common forms of pancreatogenic diabetes involve sustained exocrine disease leading to ductal obstruction, acinar inflammati...
Source: Diabetologia - Category: Endocrinology Source Type: research
Conclusions: BDNF and leptin were not associated with weight Z-score or FEV1%. Serum NPY concentrations seemed to be lower in CF patients with reduced pulmonary function independently of malnutrition and inflammation. PMID: 32863993 [PubMed]
Source: Archives of Medical Science - Category: General Medicine Tags: Arch Med Sci Source Type: research
Condition:   Cystic Fibrosis-related Diabetes Interventions:   Drug: Insulin;   Device: Continuous glucose monitor (CGM) Sponsors:   Jagdeesh Ullal;   Wake Forest University Health Sciences Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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