Investigating the physiology of normothermic ex vivo heart perfusion in an isolated slaughterhouse porcine model used for device testing and training

The PhysioHeart ™ is a mature acute platform, based isolated slaughterhouse hearts and able to validate cardiac devices and techniques in working mode. Despite perfusion, myocardial edema and time-dependent fun...
Source: BMC Cardiovascular Disorders - Category: Cardiology Authors: Tags: Research article Source Type: research

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In this study, AA loading PEGylated nanostructured lipid carriers (P-AA-NLC) were prepared. P-AA-NLC were characterized for particle size distribution, polydispersity index, entrapment efficiency, X-ray powder diffraction pattern (XRD), differential scanning colorimeter (DSC) and transmission electron microscopy (TEM). The intestinal absorption, in vivo distribution, pharmacokinetics and anti-fibrosis effects of P-AA-NLC were studied compared with that of AA-NLC. In situ single-pass intestinal perfusion model shown that there are significant differences in absorption between the free and NLCs formulation. The Peff values o...
Source: Drug Development and Industrial Pharmacy - Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research
Authors: Umapathy S, Thulasi R, Gupta N, Sivanadhan S Abstract The aim and objectives of this study were as follows: (i) to perform automated segmentation of knee thermal image using the regional isotherm-based segmentation (RIBS) algorithm and segmentation of ultrasound image using the image J software; (ii) to implement the RIBS algorithm using computer-aided diagnostic (CAD) tools for classification of rheumatoid arthritis (RA) patients and normal subjects based on feature extraction values; and (iii) to correlate the extracted thermal imaging features and colour Doppler ultrasound (CDUS) features in the knee re...
Source: Biomedizinische Technik/Biomedical Engineering - Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research
Condition:   Cesarean Section Complications Intervention:   Device: Masimo Radical-7® Pulse CO-Oximeter® Sponsor:   Antalya Training and Research Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
The clinical use of vasoactive drugs aims to improve hemodynamic variables and thereby maintain or restore adequate perfusion and oxygenation in accordance with metabolic demands. A main focus in the management of patients with brain pathology during surgery and neurointensive care is restoring and/or maintaining adequate cerebral perfusion pressure in order to ensure cerebral blood flow in accordance with metabolic demands. One commonly used clinical strategy is the administration of vasoactive drugs aiming to increase mean arterial blood pressure and thereby cerebral perfusion pressure. Here, we first describe the anatom...
Source: Journal of Neurosurgical Anesthesiology - Category: Anesthesiology Tags: Review Articles Source Type: research
AbstractPurpose of reviewEndovascular thrombectomy (ET), the standard of treatment for emergent large vessel occlusion (ELVO) strokes, has been subject to rigorous efforts to further improve its usage and delivery for optimised patient outcomes. This review aims to provide an outline and discussion about the recently established and emerging recommendations regarding endovascular treatment of stroke.Recent findingsThe indications for ET have expanded continually, with perfusion imaging now enabling selection of patients presenting 6 –24 h after last-known-well, and improved device and operator proficiency allowi...
Source: Current Treatment Options in Cardiovascular Medicine - Category: Cardiology Source Type: research
ConclusionsThese results suggest that the impaired CBF autoregulation associated with placental ischemia is due, at least in part, to activation of the AT1 receptor and that the RAS may interact with other placental factors to promote cerebrovascular changes common to preeclampsia.
Source: Biology of Sex Differences - Category: Biology Source Type: research
We aimed to investigate the relationship between the perioperative hemodynamic parameters and the occurrence of cardiac surgery-associated acute kidney injury.
Source: BMC Nephrology - Category: Urology & Nephrology Authors: Tags: Research article Source Type: research
This is a previously healthy male teenager who was awoken by chest pain.  He was seen at another hospital and found to have a slightly elevated troponin, then underwent a CT pulmonary angiogram (PE) protocol which revealed a right sided pneumonia.  He was treated with Ceftriaxone and azithromycin.p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px Calibri; background-color: #fefefe}The pain is described as located in the midsternal area, radiating to the right arm, described as 8-9/10 and worse with deep inspirations.  He endorsed cough, fever, and body aches in the previous day...
Source: Dr. Smith's ECG Blog - Category: Cardiology Authors: Source Type: blogs
AbstractObjectiveTo report our experience with the use of intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) and dynamic contrast-enhanced (DCE)-MRI in bone marrow before and after administration of granulocyte colony-stimulating factor (GCSF). Moreover, a small series of patients with bone metastases from breast cancer have been evaluated by IVIM DW-MRI and DCE-MRI before and after GCSF administration.Materials and methodsWe studied with IVIM-MRI and DCE-MRI 14 patients with rectal or uterine cervix cancer studied before and 4 –18 days after administration of GCSF; the second MR examination wa...
Source: La Radiologia Medica - Category: Radiology Source Type: research
Advances in X-ray computed tomography (CT) over the past 20 years have enabled non-invasive imaging of the coronary arteries, as well as cardiac structure and function. Coronary computed tomography angiography (CTA) has emerged as an accurate non-invasive imaging modality for identifying the anatomic severity of coronary stenoses (1 –3). Similar to other anatomic coronary imaging, coronary CTA alone has been limited in its ability to define the hemodynamic significance of coronary stenoses (4). Since the identification of the presence and severity of ischemia are important parameters for selecting between invasive an...
Source: Journal of Cardiovascular Computed Tomography - Category: Radiology Authors: Source Type: research
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