A randomized Phase I/II study to evaluate safety and reactogenicity of a heat-stable rotavirus vaccine in healthy adults followed by evaluation of the safety, reactogenicity, and immunogenicity in infants

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Source: Human Vaccines and Immunotherapeutics - Category: Allergy & Immunology Authors: Source Type: research

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Condition:   Rotavirus Gastroenteritis Interventions:   Biological: Rotavirus RV3 Vaccine (Bio Farma);   Other: Placebo Sponsor:   PT Bio Farma Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
T. Nakaggomi
Source: Emerging Infectious Diseases Journal - Category: Infectious Diseases Source Type: research
Conclusions: Our review highlights similarities and differences in the application of the test-negative design that deserve further examination. If vaccination reduces disease severity in breakthrough infections, particular care must be taken in interpreting vaccine effectiveness estimates from test-negative design studies.
Source: Epidemiology - Category: Epidemiology Tags: Methods Source Type: research
With rotavirus vaccination rates lagging behind those of other childhood vaccines, many children still suffer from severe rotavirus disease. Here are five things to know.CDC Expert Commentary
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Pediatrics Commentary Source Type: news
This study examined the RV vaccine effectiveness against risk of hospitalization based on a retrospective cohort study and the impact of public expense for the RV vaccine on this regional RV gastroenteritis epidemic. The vaccination coverage was significantly higher in children in Shari and Koshimizu than in Abashiri (87.8% vs. 42.7%, respectively, p
Source: Japanese Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Jpn J Infect Dis Source Type: research
Human group A rotavirus is the leading cause of severe acute gastroenteritis in young children worldwide. Immunization programs have reduced the disease burden in many countries. Vaccination coverage in the Au...
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: Tags: Research article Source Type: research
Conclusions: The present study found RVA positivity in 30.62% of children with gastroenteritis, with the highest burden among 24–36 months old. The predominant genotypes were G1, G3, and P[8]. Further large-scale/multicentric studies should be conducted to document the diversity of circulating RVA genotypes in this region for giving inputs for vaccination strategy.
Source: Journal of Global Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
Authors: Kotsopoulos N, Haitsma G, Connolly MP, Standaert B Abstract Background: The economics of rotavirus gastroenteritis in infants
Source: Expert Review of Pharmacoeconomics and Outcomes Research - Category: Health Management Tags: Expert Rev Pharmacoecon Outcomes Res Source Type: research
CONCLUSIONS: Even though the evidence shows a DS-1-like change trend, data from studies conducted in Latin America and the Caribbean are diverse and still not sufficient to assess the impact of vaccines on viral ecology or if genetic diversity is influenced by natural mechanisms of fluctuation. PMID: 31771863 [PubMed - as supplied by publisher]
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
Conclusions: Enteropathogen infections were common around the time of rotavirus vaccination in rural Zimbabwean infants but did not explain poor RVV immunogenicity and were not reduced by a package of household-level WASH interventions.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Vaccine Reports Source Type: research
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