M044 rapid paclitaxel desensitization in a patient with good response to standard protocol

Cancer is one of the leading causes of death worldwide, with a high incidence of hypersensitivity reactions (HSR) to first-line chemotherapeutic agents. There is a 9% risk of HSR to taxanes during the first infusion. Two mechanisms could explain the immediate HSR to taxanes: complement activation caused by the emulsifying agents used in its formulation and an IgE-mediated reaction.

Source: Annals of Allergy, Asthma and Immunology - October 31, 2019 Category: Allergy & Immunology Authors: G. Herrera Escalante, S. Gonzalez-Diaz, C. De Lira-Quezada, R. Villarreal Gonzalez, I. Penafiel Quinteros, A. Rodriguez Casas Source Type: research