M166 estrogen-dependent angioedema responsive to anastrozole in a male with familial hyperestrogenemia and hereditary cancer risk

A 44-year-old man was evaluated for recurrent angioedema manifested as more than 10 discrete episodes with swelling of the posterior pharynx and uvula, without urticaria, that would subside spontaneously over 24 hours. These episodes were first noted 2 years ago, were worsened by alcohol, and were not responsive to antihistamines. Medical history was significant for hyperestrogenism, that worsened with testosterone treatment for infertility. His primary family history revealed a father and brother with gynecomastia, a mother with endometrial cancer, and a sister with Lynch syndrome.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research

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Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
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Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
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Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
Publication date: Available online 24 September 2020Source: The Lancet Respiratory MedicineAuthor(s): Christopher E Brightling, Mina Gaga, Hiromasa Inoue, Jing Li, Jorge Maspero, Sally Wenzel, Samopriyo Maitra, David Lawrence, Florian Brockhaus, Thomas Lehmann, Caterina Brindicci, Barbara Knorr, Eugene R Bleecker
Source: The Lancet Respiratory Medicine - Category: Respiratory Medicine Source Type: research
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Source: The Lancet Respiratory Medicine - Category: Respiratory Medicine Source Type: research
Selective estrogen receptor modulators (SERMs) are an increasingly important therapeutic modality that are used by clinicians on a daily basis. Unfortunately, clinicians have a limited understanding regarding the underlying mechanism(s) of how SERMs function and their increasingly useful role in the treatment of estrogen-responsive target tissues such as the breast, bone, vagina, uterine endometrium, and brain. This review will provide a basic understanding of our current knowledge of SERM pharmacodynamics and will highlight the clinical applications of Food and Drug Administration–approved SERMs in the treatment of ...
Source: Menopause - Category: OBGYN Tags: Clinical Corner: Invited Review Source Type: research
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Source: Journal of Obstetrics and Gynaecology Canada : JOGC - Category: OBGYN Tags: J Obstet Gynaecol Can Source Type: research
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Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
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