P104 total nasal symptom score improvement with benralizumab for patients with severe, eosinophilic asthma

Patients with asthma often experience nasal symptoms, from comorbid allergic rhinitis and sinusitis to nasal polyposis. We evaluated reductions in nasal symptoms as a function of baseline blood eosinophil counts (BEC) for patients in a Phase IIb study of benralizumab.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research

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We examined the impact of mepolizumab on clinically significant exacerbations and health-related quality of life (HRQoL) in patients with severe eosinophilic asthma and upper respiratory comorbidities.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
AbstractPurpose of ReviewOccupational rhinitis (OR), an inflammatory disease of the nose, refers to any nasal symptoms reported to be work-related. The purpose of this review is to provide a current overview of the classification, diagnosis, and treatment of OR.Recent FindingsOccupational rhinitis (OR) can further be  classified into allergic or non-allergic depending on the causative agent(s) and pathogenesis. Presenting symptoms are similar to non-OR including nasal congestion, anterior and posterior rhinorrhea, sneezing, and nasal itching. Despite its high prevalence in a spectrum of workplaces, OR is under reporte...
Source: Current Allergy and Asthma Reports - Category: Allergy & Immunology Source Type: research
Conclusions: Allergic rhinitis is common comorbidity of asthma that interrelated to asthma control. Identifiable allergens could be detected AR in asthma by SPT. Therefore, reduction of allergens exposure could become preventive approach for asthma patients with AR.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Allergy and immunology Source Type: research
ConclusionsSM are a  common sensitization in the study population and should be included in standard skin prick test arrays. Cross sensitization to house dust mites is limited and nasal symptoms are most frequent. Nasal provocation testing is necessary to secure clinical diagnosis of allergy and further research is ne eded to evaluate the clinical relevance of the high sensitization rates found for intradermal testing.
Source: Allergo Journal International - Category: Allergy & Immunology Source Type: research
The Journal of Allergy was launched in November 1929. The inaugural issue had 6 original articles covering asthma, ragweed pollen, bacterial allergy, a case report, sinusitis, and classification of specific sensitivities. The first editorial emphasized that the  Journal “has been launched as a medium for the presentation of papers concerning the clinical aspects of specific hypersensitivities in human beings.”1 Twenty years later, an editorial celebrating that anniversary stated, “A new era in allergy is coming into being, due to the ‘rediscover y’ that human hypersensitiveness ...
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Editorial Source Type: research
AbstractPurpose of ReviewStaphylococcus aureus (S. aureus) is correlated with the development of persistent severe inflammatory disease of the upper airway including chronic rhinosinusitis with nasal polyps (CRSwNP). The presence ofS. aureus is associated with atopic disease including allergic rhinitis and atopic dermatitis and is associated with poor outcomes.Recent FindingsSeveral different strains ofS. aureus generate different toxins and gene products that can account for organism pathogenicity.S. aureus bacteria and its antigens shape the bacterial and fungal microbiome and the mucosal niche which generates host respo...
Source: Current Allergy and Asthma Reports - Category: Allergy & Immunology Source Type: research
, Kirdar S, Karul A Abstract The effects of comorbidities on systemic inflammation markers in stable asthmatics and the consequences of such effects have not been well evaluated. We aimed to evaluate the effect of comorbidities on clinical manifestations and systemic inflammation in asthmatic patients under control. The study group consisted of asthmatic patients who applied to our pulmonology outpatient clinic and volunteered to participate. 120 clinically stable asthma patients (71 females and 49 males) and 35 healthy controls (19 females and 16 males) with similar age, gender, and body mass index distributions ...
Source: Iranian Journal of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Iran J Allergy Asthma Immunol Source Type: research
Purpose of review The prevalence of obesity and allergic diseases, such as asthma and allergic rhinitis, is increasing worldwide not only in adults, but also in children. Experimental and clinical studies have demonstrated the effect of obesity not only on asthma, but also on other allergic diseases. Recent findings Allergic diseases, such as asthma and allergic rhinitis, are common chronic inflammatory diseases of the airways. Obesity is an increasingly common pediatric disease and is a risk factor for the development of asthma in that obese patients with asthma tend to have more severe asthma that does not respond w...
Source: Current Opinion in Allergy and Clinical Immunology - Category: Allergy & Immunology Tags: RHINITIS, SINUSITIS AND UPPER AIRWAY DISEASE: Edited by Ruby Pawankar and David P. Skoner Source Type: research
A 51-year old man with past medical history of allergic rhinitis was admitted to the hospital and treated for a right sided multi-lobar pneumonia. He presented with progressively worsening dry cough, malaise and diffuse (hip, knee, elbow, hands) joint pain. He had a history of multiple episodes of sinusitis and upper respiratory tract infections in the preceding six months requiring steroids and antibiotics with varying responses. A CBC revealed eosinophil count of> 9 eosinophils x 109/L. A BAL revealed over 90% eosinophils.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: M212 Source Type: research
Conclusion The results obtained from this research shows, in general, the fragility in the social and political infrastructure necessary to improve the living conditions of populations, particularly those that depend on family agriculture in drought prone areas. The conditions of social, economic and environmental vulnerabilities presented in the region can be amplified by the drought process, and can aggravate the impacts resulting drought events, thus disadvantaging the population of this region, as shown in the Fig. 1. The general perception of the interviewees of the health sector shows an agreement with what is found...
Source: PLOS Currents Disasters - Category: International Medicine & Public Health Authors: Source Type: research
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