P206 analysis of spirometry measurements as predictors of aspirin desensitization outcomes

While it is typical practice for the FEV1 to be optimized prior to aspirin desensitization, it is not entirely clear if other spirometry measures relate to aspirin desensitization outcome.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research

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Conclusion This study suggests that specific questions about triggers and severity of wheeze, measurement of FeNO and BPT by methacholine or exercise contribute more to the diagnosis of asthma in school-aged children than spirometry, bronchodilator reversibility and skin-prick tests.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Asthma and allergy, Paediatric pulmonology Original Articles: Asthma and paediatrics Source Type: research
Conclusions: Our study suggest the functional activity of IgE to SEs in severe asthmatic patients. These results can be clinically relevant in patients not sensitized to perennial allergens who can be candidates to anti-IgE therapy.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Allergy and immunology Source Type: research
Introduction: In differential diagnosis of allergic diseases, such as asthma, chronic urticaria (CU) and Hymenoptera venom allergy (HVA), the complete blood count (CBC) and spirometry are one of the crucial examinations.Aims and Objectives: To assess the blood lymphocytes, monocytes, basophiles and neutrophils and spirometry parameters in patients with asthma, CU and HVA in comparison to healthy subjects.Methods: The study involved 48 patients with asthma, 19 with CU, 12 with HVA and 17 healthy individuals. Participants had a spirometry and CBC examinations performed.Results: The absolute values of neutrophils were highest...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Allergy and immunology Source Type: research
Aim: Examination of patients (pts) with two broncho-obstructive diseases (A and COPD) requires addressing the issue: is it originally A or COPD? We looked at the problem from COPD.Material and Methods: We studied 38 smokers with COPD II-III stages (age–61.4±3.8 yrs, pack/year–28.8±4.3) repeatedly (3-8 yrs) in stable phase on adequate therapy. Measurements included clinical status, spirometry with bronchoobstructive reversibility test (BORT) and allergic markers: blood eosinophil level (E), common IgE level (cIgE) in plasma, Phadiatop (Ph) in serum. Each patient underwent from 3 to 9 (6.2±1....
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Allergy and immunology Source Type: research
Aspergillus (ASP) sensitization is frequent in severe asthma (SA). Aspergillus-associated disease, such as allergic bronchopulmonary aspergillosis (ABPA) and chronic pulmonary aspergillosis (CPA) can be associated with bronchiectasis (B). B is a comorbidity in patients with SA. We investigated the prevalence and the characteristics of Aspergillus-associated bronchiectasis in 73 consecutive immunocompetent patients with SA.Methods: All the patients underwent assessment of history, spirometry, FENO, circulating eosinophils (EOS), serum total IgE, IgE-ASP (increased if> 0.10 kUA/L), and IgG-ASP (increased if>40 U/ml), c...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Allergy and immunology Source Type: research
Conclusions: Despite guideline recommendations, PFT to diagnose and manage asthma remains low from 2000-2016 in Ontario. Although there are decreasing trends in hospitalizations and ED visits, it is important to promote the use of PFT to objectively diagnose and manage asthma in order to further reduce acute care and improve the health status of people with asthma.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Epidemiology Source Type: research
Conclusions: Our observations suggest detrimental effect of IFN in asthma pathogenesis.The study was supported by RFBR (#18-54-53019).
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Allergy and immunology Source Type: research
Conclusions: The COPD patients included in this study had no specific clinical characteristics, depending on blood eosinophil count. Further larger prospective studies are needed.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Allergy and immunology Source Type: research
Introduction: Data on remission of asthma in adults in the world is limited, and in the Russian Federation is not presented. The aim of the study was to determine clinical, functional and laboratory factors associated with remission of atopic asthma in adults.Methods: A retrospective analysis of 313 outpatient records of adult patients with atopic asthma was carried out and then a telephone survey for 181 respondents was conducted. The median duration of observation was 8 [5;15] years. Further, 53 people with atopic asthma and 30 people without allergic diseases were examined. Clinical and laboratory (eosinophil count in p...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Allergy and immunology Source Type: research
The association between asthma and obesity has been obeserved in many studies but the underlying mechanisms are poorly understood. Aim of the work is to evaluate the respiratory function (forced spirometry, residual volume [RV], DLCO, oscillometry [IOS] and serum concentration of IL-10, IL1-β, TGF-β1, TNF-α, IL-33, adiponectin, leptin in 28 obese non asthmatic children (O+NA) (20 M, median age: 11,7 yrs), compared with 28 obese asthmatic (O+A) and 28 non-obese asthmatic (NO+A), overlapped for sex and age, The results are the following:O+NAMedian (1-3 quartile)O+ANO+AO+NA vs O+AO+NA vs NO+Ap valueO+A vs NO+A...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Paediatric asthma and allergy Source Type: research
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