D451 clinical activity of ak002, an anti-siglec-8 antibody, in severe allergic conjunctivitis and comorbid atopic diseases

Severe allergic conjunctivitis (AC) can lead to debilitating ocular symptoms with a risk of vision loss. Driven primarily by conjunctival mast cells and eosinophils, AC is also commonly associated with atopic conditions such as atopic dermatitis, asthma, and rhinitis. AC can present in various forms including atopic keratoconjunctivitis (AKC), vernal keratoconjunctivitis (VKC), and perennial allergic conjunctivitis (PAC). AK002 is an anti-Siglec-8 antibody that selectively depletes eosinophils and inhibits mast cells.

Source: Annals of Allergy, Asthma and Immunology - October 31, 2019 Category: Allergy & Immunology Authors: T. Levine, J. Tauber, Q. Nguyen, S. Anesi, P. Chang, G. Berdy, C. Lin, D. Chu, A. Kantor, H. Rasmussen, B. Singh, A. Chang, A. Kamboj, B. Jeng, V. Jhanji, S. Foster Source Type: research