D451 clinical activity of ak002, an anti-siglec-8 antibody, in severe allergic conjunctivitis and comorbid atopic diseases

Severe allergic conjunctivitis (AC) can lead to debilitating ocular symptoms with a risk of vision loss. Driven primarily by conjunctival mast cells and eosinophils, AC is also commonly associated with atopic conditions such as atopic dermatitis, asthma, and rhinitis. AC can present in various forms including atopic keratoconjunctivitis (AKC), vernal keratoconjunctivitis (VKC), and perennial allergic conjunctivitis (PAC). AK002 is an anti-Siglec-8 antibody that selectively depletes eosinophils and inhibits mast cells.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research

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Source: International Archives of Allergy and Immunology - Category: Allergy & Immunology Source Type: research
CONCLUSIONS: The differences between mild and moderate-to-severe asthma enhance asthma phenotype characterization, with respect to comorbidities, and indicate varied etiologies. PMID: 31017024 [PubMed - as supplied by publisher]
Source: Journal of Asthma - Category: Respiratory Medicine Tags: J Asthma Source Type: research
AbstractPurpose of ReviewMost children and adolescents with allergic rhinitis (AR) present extra-nasal multimorbid conditions, including conjunctivitis, asthma, atopic dermatitis, rhinosinusitis, or seromucous otitis. Additionally, they may present nasal obstructive disorders, such as septal deformity, turbinate enlargement, and adenoidal hyperplasia, which worsen nasal symptoms, especially nasal obstruction. This is a narrative review on the current state of the concomitant presence of AR and one or more multimorbidities.Recent FindingsThe presence of AR and one or more accompanying multimorbidities is associated to a hig...
Source: Current Allergy and Asthma Reports - Category: Allergy & Immunology Source Type: research
Allergic conjunctival diseases (ACDs) are defined as conjunctival inflammatory conditions associated with a type I allergy accompanied by some subjective and objective symptoms1. ACDs are broadly divided into five types according to the presence of proliferative changes, atopic dermatitis (AD), and the presence/absence of mechanical irritation (i.e., seasonal allergic conjunctivitis (SAC), perennial allergic conjunctivitis (PAC), atopic keratoconjunctivitis (AKC), vernal keratoconjunctivitis (VKC) and giant papillary conjunctivitis (GPC)).
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research
Authors: Klimek L, Wollenberg B, Guntinas-Lichius O, Pfaar O, Koennecke M Abstract Allergies are one of the most common chronic diseases in childhood, contributing to a tremendous medical and economical burden in health care systems of most industrialized countries. The development of allergies is dependent on a complex interaction of-among others-environmental factors, nutrition, genetic and epigenetic mechanisms as well as the microbiome. These diverse factors can influence early life immune regulation including innate and adaptive immune mechanisms in a complex fashion. In case of any Childhood al...
Source: HNO - Category: ENT & OMF Tags: HNO Source Type: research
Abstract BACKGROUND: Dysregulation of the coagulation cascade and fibrinolysis system may play an etiologic role in many diseases. Allergic diseases such as bronchial asthma, atopic dermatitis, and conjunctivitis are also associated with fibrin accumulation caused by a change in hemostasis. However, only a few studies have dealt with the relationship between allergic rhinitis (AR) and the coagulation system. OBJECTIVE: We investigated the difference of coagulation and fibrinolysis cascade components between an AR mouse model and a control mice. METHODS: BALB/c mice were sensitized and challenged with ova...
Source: American Journal of Rhinology and Allergy - Category: ENT & OMF Authors: Tags: Am J Rhinol Allergy Source Type: research
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Source: International Journal of Immunopathology and Pharmacology - Category: Allergy & Immunology Tags: Int J Immunopathol Pharmacol Source Type: research
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Source: Italian Journal of Pediatrics - Category: Pediatrics Source Type: research
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Source: Clinical Reviews in Allergy and Immunology - Category: Allergy & Immunology Source Type: research
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