M271 ctla-4 haploinsufficiency: the case for whole exome sequencing in common variable immune deficiency (cvid)

We describe a case in which whole exome sequencing (WES) in a patient with CVID and associated lung disease revealed a new option for therapy.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research

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Influenza activity is widespread or regional in more than half the country weeks earlier than last year, according to the CDC.Medscape Medical News
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Infectious Diseases News Source Type: news
An oral, inactivated enterotoxigenic Escherichia coli (ETEC) vaccine (ETVAX) is safe and immunogenic in children, according to a new phase-1/2 trial.Reuters Health Information
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Infectious Diseases News Source Type: news
Publication date: Available online 9 December 2019Source: Life SciencesAuthor(s): Liqun Shang, Li Wang, Xiaolan Shi, Ning Wang, Long Zhao, Jing Wang, Cuicui LiuAbstractAimsThe present study explored the function and regulatory mechanism of High mobility group box 1 (HMGB1) in asthma.Main methodsOVA (ovalbumin)-induced asthmatic mice model and LPS-treated cellular model were established in this study. Airway inflammation was measured through detecting the expression of IL-4, IL-5, IL-13 and Interferon-γ (IFN-γ) in serum and BALF (bronchoalveolar lavage fluid) by ELISA kits. Bioinformatics predictive analysis, Ch...
Source: Life Sciences - Category: Biology Source Type: research
Background: Pulmonary eosinophilia (PE) occurs due to various causes, such as infections, drugs, autoimmune processes, and obstructive lung diseases. Infiltration of eosinophils is found in the airways, interstitium and alveoli, resulting inflammation and tissue injury. The airway secreted mucins MUC5AC and MUC5B may be associated with the pathogenesis of PE; MUC5AC production can be increased by eosinophils, and MUC5B plays a role in an ameliorating pathway for eosinophilia. However, the composition of the airway secreted mucins in PE has not been evaluated yet.Aims: To determine the concentrations of the airway secreted ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Allergy and immunology Source Type: research
Authors: Fredricson AS, Khodabandehlou F, Weiner CK, Naimi-Akbar A, Adami J, Rosén A Abstract Temporomandibular joint disorders (TMJD) involve orofacial pain and functional limitations that may limit important daily activities such as chewing and speaking. This observational case-control study attempted to identify factors associated with TMJD development, particularly inflammation. The study participants were patients treated at Karolinska University Hospital, Stockholm, Sweden. The cases were patients who received a diagnosis of TMJD, chronic closed lock, or painful clicking and were treated surgically dur...
Source: Journal of oral science - Category: Dentistry Tags: J Oral Sci Source Type: research
AbstractThis review reports main progresses in various pediatric issues published in Italian Journal of Pediatrics and in international journals in 2016. New insights in clinical features or complications of several disorders may be useful for our better understanding. They comprise severe asthma, changing features of lupus erythematosus from birth to adolescence, celiac disease, functional gastrointestinal disorders, Moebius syndrome, recurrent pneumonia. Risk factors for congenital heart defects, Kawasaki disease have been widely investigated. New diagnostic tools are available for ascertaining brucellosis, celiac diseas...
Source: Italian Journal of Pediatrics - Category: Pediatrics Source Type: research
Who has never had a cough? I bet no one can raise their hand. We see this in clinic all the time. But chronic cough— one that lasts at least eight weeks — can be hard for patients to deal with and difficult for doctors to figure out. In the October 20, 2016 issue of the New England Journal of Medicine, lung experts describe a step-by-step approach doctors can use to help treat patients with chronic cough. Most often a prolonged cough is due to one of the “usual suspects.” But when it’s not, we have a long list of increasingly rarer conditions that we should run through and rule out. If it isn&...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Cold and Flu Health Lung disease Source Type: blogs
Conclusions Safe, effective, affordable homeopathic immunizations exist for almost every illness now targeted by unsafe, costly, failed conventional vaccinations. If the goal were to provide protection from disease in a safe manner, why aren’t these safe, inexpensive homeopathic options made available to the public on a large scale? Millions of dollars in healthcare costs would be saved by using a less expensive immunization. Most significant would be the reduction of vaccine-caused diseases including autism, asthma, allergies, autoimmune disorders, diabetes, and cancer. The health of Americans would improve in drama...
Source: vactruth.com - Category: Allergy & Immunology Authors: Tags: Logical Michelle Goldstein Recent Articles Top Stories homeopathic vaccination homeopathic vaccines truth about vaccines Source Type: blogs
Table of Contents A1 Pirfenidone inhibits TGF-b1-induced extracellular matrix production in nasal polyp-derived fibroblasts Jae-Min Shin, Heung-Man Lee, Il-Ho Park A2 The efficacy of a 2-week course of oral steroid in the treatment of chronic spontaneous urticaria refractory to antihistamines Hyun-Sun Yoon, Gyeong Yul Park A3 The altered distribution of follicular t helper cells may predict a more pronounced clinical course of primary sjögren’s syndrome Margit Zeher A4 Betamethasone suppresses Th2 cell development induced by langerhans cell li...
Source: World Allergy Organization Journal - Category: Allergy & Immunology Source Type: research
Conclusion A growing number of today’s children suffer from vaccine damage. Most individuals do not make the connection between health problems and vaccines. When asked about the cause of autoimmune disorders, asthma, allergies, diabetes, learning disabilities, attention deficit disorder, autism, and other common childhood diseases and illness, the majority of health care providers advise patients that the causes are unknown. Doctors, including most integrative physicians, fail to make the connection to vaccines. It takes one moment to permanently damage the health of an adult or child, but t...
Source: vactruth.com - Category: Allergy & Immunology Authors: Tags: Logical Michelle Goldstein Top Stories autoimmune disorders gardasil HPV Vaccine Medical Authority vaccine injury Source Type: blogs
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