The potential for gas-free measurements of absolute oxygen metabolism during both baseline and activation states in the human brain

Publication date: Available online 10 November 2019Source: NeuroImageAuthor(s): Eulanca Y. Liu, Jia Guo, Aaron B. Simon, Frank Haist, David J. Dubowitz, Richard B. BuxtonAbstractQuantitative functional magnetic resonance imaging methods make it possible to measure cerebral oxygen metabolism (CMRO2) in the human brain. Current methods require the subject to breathe special gas mixtures (hypercapnia and hyperoxia). We tested a noninvasive suite of methods to measure absolute CMRO2 in both baseline and dynamic activation states without the use of special gases: arterial spin labeling (ASL) to measure baseline and activation cerebral blood flow (CBF), with concurrent measurement of the blood oxygenation level dependent (BOLD) signal as a dynamic change in tissue R2*; VSEAN to estimate baseline O2 extraction fraction (OEF) from a measurement of venous blood R2, which in combination with the baseline CBF measurement yields an estimate of baseline CMRO2; and FLAIR-GESSE to measure tissue R2′ to estimate the scaling parameter needed for calculating the change in CMRO2 in response to a stimulus with the calibrated BOLD method. Here we describe results for a study sample of 17 subjects (8 female, mean age = 25.3 years, range 21–31 years). The primary findings were that OEF values measured with the VSEAN method were in good agreement with previous PET findings, while estimates of the dynamic change in CMRO2 in response to a visual stimulus were in good agreement between ...
Source: NeuroImage - Category: Neuroscience Source Type: research

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Conclusion: The development of LRSS pneumatization affects the removal rate of CS tumors in PAs. Preoperative analysis of LRSS development should be considered when planning EES against PA with CS invasion. PMID: 31819816 [PubMed]
Source: Surgical Neurology International - Category: Neurosurgery Tags: Surg Neurol Int Source Type: research
Conclusion: Medically fragile patients with significant cervical spondylotic myelopathy but major comorbidities precluding major surgery successfully underwent MI cervical decompressions. PMID: 31819813 [PubMed]
Source: Surgical Neurology International - Category: Neurosurgery Tags: Surg Neurol Int Source Type: research
Conclusion: GCTs were thought to be benign tumors with slow growth, but they could potentially possess aggressive features and invade into surrounding structures as described in this case. OTE can be a rare MRI finding of GCTs. Only one case of GCT-related OTE has been reported in literature to our best knowledge. PMID: 31819811 [PubMed]
Source: Surgical Neurology International - Category: Neurosurgery Tags: Surg Neurol Int Source Type: research
We describe an extremely rare case of SFT in the left preauricular region. The tumor lesion had gradually grown without pain or facial paralysis. Magnetic resonance imaging scan showed a circumscribed mass with high signal intensity on Gd-DTPA-enhanced T1-weighted images measuring approximately 3.0 cm in diameter. The tumor lesion was excised completely. Histological examination of the surgical specimen revealed proliferation of spindle tumor cells with a patternless pattern. Various amounts of collagen bundles intervened in the spindle tumor cells. The cellular atypia of the tumor cells was weak. Immunohistochemical studi...
Source: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology - Category: ENT & OMF Source Type: research
CONCLUSIONS: The results of this study suggest that the vascular imaging should be included in the assessment of disease activity in TAK. PMID: 31820717 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
Authors: Livshetz I, Meghpara MB, Karam JA, Salem HS, Mont MA, Hassan OT, Goldberg BA Abstract INTRODUCTION: The tibial tubercle-trochlear groove (TT-TG) distance is commonly used to evaluate and guide treatment for patellar instability. There is limited data available regarding TT-TG variability based on patient demographics and anthropometric factors. MATERIALS AND METHODS: TT-TG was measured on magnetic resonance imaging (MRI) for 384 consecutive adult patients. Demographic information for the corresponding was then gathered from the medical record and analyzed. Demographic variables analyzed included age, s...
Source: Surgical Technology International - Category: Surgery Tags: Surg Technol Int Source Type: research
CONCLUSIONS: 82RbCl PET produces high-contrast uptake of both recurrent disease and radiation necrosis compared to normal brain. However, no statistically significant difference was found between recurrent tumor and radiation necrosis. PMID: 31820882 [PubMed - as supplied by publisher]
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research
Publication date: Available online 11 December 2019Source: NeuroImageAuthor(s): Kenneth Wengler, Xiang He, Anissa Abi-Dargham, Guillermo HorgaAbstractNeuromelanin-sensitive MRI (NM-MRI) provides a noninvasive measure of the content of neuromelanin (NM), a product of dopamine metabolism that accumulates with age in dopamine neurons of the substantia nigra (SN). NM-MRI has been validated as a measure of both dopamine neuron loss, with applications in neurodegenerative disease, and dopamine function, with applications in psychiatric disease. Furthermore, a voxelwise-analysis approach has been validated to resolve substructure...
Source: NeuroImage - Category: Neuroscience Source Type: research
Publication date: Available online 11 December 2019Source: NeuroImageAuthor(s): Thomas A.W. Bolton, Valeria Kebets, Enrico Glerean, Daniela Zöller, Jingwei Li, B.T. Thomas Yeo, César Caballero-Gaudes, Dimitri Van De VilleAbstractThe impact of in-scanner motion on functional magnetic resonance imaging (fMRI) data has a notorious reputation in the neuroimaging community. State-of-the-art guidelines advise to scrub out excessively corrupted frames as assessed by a composite framewise displacement (FD) score, to regress out models of nuisance variables, and to include average FD as a covariate in group-level analys...
Source: NeuroImage - Category: Neuroscience Source Type: research
ConclusionsManagement of delivery in cases of suspected autosomal recessive renal polycystic kidney disease needs to be discussed because of the risk of abdominal dystocia. The route and timing of delivery depend on the size of the fetal abdominal circumference and the gestational age. The rate of kidney growth must also be taken into account.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
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