Study challenges the “seductive” amyloid hypothesis of Alzheimer’s disease (AD)

Conclusions and Relevance:  Higher vascular risk is associated with smaller whole-brain volume and greater white matter–hyperintensity volume at age 69 to 71 years, with the strongest association seen with early adulthood vascular risk. There was no evidence that higher vascular risk influences amyloid deposition, at least up to age 71 years. Reducing vascular risk with appropriate interventions should be considered from early adulthood to maximize late-life brain health. The Study in Context: Cognitive training, diet, exercise, and vascular management seen to improve cognition even in people with genetic predisposition for dementia (APOE e4) New studies reinforce Education and Cognitive Reserve –instead of drugs targeting beta amyloid– as most promising avenue to prolong cognitive health and reduce dementia risk Study: 46.7 million Americans have Alzheimer’s Disease brain pathology today, so it’s urgent to prevent or at least delay progression to clinical disease Report: 35% of worldwide dementia cases could be prevented by modifying these 9 modifiable risk factors
Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Health & Wellness amyloid hypothesis beta-amyloid beta-amyloid status brain health brain pathology cardiovascular risk dementia risk Framingham midlife preventive vascular health Source Type: blogs