Dying to Die – The Janet Adkins Story

In 1990, Dr. Jack Kevorkian was just beginning his work in the death with dignity movement. Janet Adkins, who made a choice to die after being diagnosed with early Alzheimer’s disease, was his first assisted suicide patient. This week, Susan Clevenger publishes Dying to Die – The Janet Adkins Story. (Amazon) Clevenger interviewed and recorded stories from Janet’s family and closest friends, transcribed TV videos and read countless magazine and news stories. Her source material included Janet’s personal journals and letters from family and friends that the family had saved over the years.
Source: blog.bioethics.net - Category: Medical Ethics Authors: Tags: Health Care syndicated Source Type: blogs

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I tried to kill my father for years. To be fair, I was following his wishes. He’d made it clear that when he no longer recognized me, when he could no longer talk, when the nurses started treating him like a toddler, he didn’t want to live any longer. My father was 58 years old when he was diagnosed with Alzheimer’s disease. He took the diagnosis with the self-deprecating humor he’d spent a lifetime cultivating, constantly cracking jokes about how he would one day turn into a zombie, a walking corpse. We had a good 10 years with him after the diagnosis. Eventually, his jokes came true. Seven years ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Alzheimer's Disease Source Type: news
Alzheimer's disease and other progressive neurodegenerative dementias are growing as the population ages. Managing dementia is challenging from economic, societal, and ethical perspectives. One significant ethical issue concerns people who want to avoid living with advanced dementia. Current strategies (suicide and traditional advance directives) are suboptimal or inadequate. Stopping eating and  drinking by advance directive (SED by AD) is a better potential solution.
Source: Journal of the American Medical Directors Association - Category: Health Management Authors: Tags: Care Decisions at the End of Life Source Type: research
Traumatic brain injury (TBI) is a leading cause of death and disability, contributing to ~30% of all injury-related deaths in the US. TBI occurs when a force transmitted to the head causes neuropathologic damage and impairment of brain function. TBI doubles risk of suicide and is the major determinant of acquired seizure disorders. TBI arising from closed head trauma (CHT) significantly increases the risk of developing Alzheimer's disease (AD), Parkinson's disease (PD) and chronic traumatic encephalopathy (CTE).
Source: Metabolism - Clinical and Experimental - Category: Biomedical Science Authors: Source Type: research
Yet depression prevalence unchanged Related items fromOnMedica New evidence on benzodiazepine link to Alzheimer ’s Men ’s dementia risk higher after androgen deprivation therapy Plans launched to curb over-use of antipsychotics Suicide no more likely in men on 5 α-reductase inhibitors GPs need more time to treat complex needs
Source: OnMedica Latest News - Category: UK Health Source Type: news
CONCLUSIONS: Advance and concurrent request EAS cases differ in age, duration of illness, and past experience. Advance request EAS cases were complicated by ambiguous directives, patients being unaware of the EAS procedure, and physicians' difficulty assessing "unbearable suffering." Notably, some concurrent request patients were quite impaired yet deemed competent by appeals to previous statements. PMID: 31537470 [PubMed - as supplied by publisher]
Source: The American Journal of Geriatric Psychiatry - Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research
Do Anti-Amyloid-β Drugs affect Neuropsychiatric Status in Alzheimer's Disease Patients? Ageing Res Rev. 2019 Aug 24;:100948 Authors: Panza F, Lozupone M, Bellomo A, Imbimbo BP Abstract In the Alzheimer's disease (AD) brain, accumulation of the amyloid-β (Aβ) peptide starts 15-20 years before clinical symptoms become apparent and is believed to be the initial event of the pathological process. Unfortunately, candidate drugs targeting production, clearance and deposition of Aβ have failed to show clinical benefit in patients with established or prodromal disease, or in cognitively no...
Source: Ageing Research Reviews - Category: Genetics & Stem Cells Authors: Tags: Ageing Res Rev Source Type: research
ONS figures show 49 is the age at which most people die by suicide Related items fromOnMedica NI drug deaths in males double in a decade Assess benzodiazepines ’ risk-benefit before use in early pregnancy Suicide no more likely in men on 5 α-reductase inhibitors New evidence on benzodiazepine link to Alzheimer ’s SSRIs raise risk of rare neonatal hypertension
Source: OnMedica Latest News - Category: UK Health Source Type: news
In conclusion, we show here that sEVs are responsible for mediating paracrine senescence and speculate that they could be involved in inducing bystander senescence during therapy-induced senescence or aging. In fact, when compared to soluble factors, sEVs have different biophysical and biochemical properties as they have a longer lifespan than do soluble factors and they are more resistant to protease degradation. The idea that blocking sEV secretion could be a potential therapeutic approach to alleviate senescence "spreading" during chemotherapy-induced senescence or in aging tissues presents itself as a very at...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
This study sought to investigate what could be learned from how these men have fared. The men were born in 1925-1928 and similar health-related data from questionnaires, physical examination, and blood samples are available for all surveys. Survival curves over various variable strata were applied to evaluate the impact of individual risk factors and combinations of risk factors on all-cause deaths. At the end of 2018, 118 (16.0%) of the men had reached 90 years of age. Smoking in 1974 was the strongest single risk factor associated with survival, with observed percentages of men reaching 90 years being 26.3, 25.7, ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In this study, compared to young mice (4 months of age), aged mice (20-22 months of age) exhibited increased left ventricular weight and cardiomyocyte volume, and showed reduction in cardiomyocyte number, together with reduced ventricular function, indicating the pathological roles of cardiomyocyte senescence in the aged heart. Heart failure can be characterized into two types depending on the level of systolic function. One is described as heart failure with reduced ejection fraction (HFrEF), another is classified as heart failure with preserved ejection fraction (HFpEF), and both types of heart failure are prevale...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
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