Hepatic exosome-derived miR-130a-3p attenuates glucose tolerance via suppressing PHLPP2 gene in adipocyte

Glucose and lipid metabolism disorder is a major risk factor for type II diabetes and cardiovascular diseases. Evidence has indicated that the interplay between the liver and adipose tissue is crucial in maintaining energy homeostasis. Recently, the interaction between two distant endocrine organs mainly focuses on the regulation of hormones and receptors. However, as a novel carrier in the inter-tissue communication, exosome plays a role in liver-fat crosstalk, but its effects on glucose and lipid metabolisms are still unclear.

Source: Metabolism - Clinical and Experimental - November 9, 2019 Category: Biomedical Science Authors: Jiahan Wu, Tao Dong, Ting Chen, Jiajie Sun, Junyi Luo, Jiajian He, Limin Wei, Bin Zeng, Haojie Zhang, Weite Li, Jie Liu, Xingping Chen, Mei Su, Yuechun Ni, Qingyan Jiang, Yongliang Zhang, Qianyun Xi Source Type: research