Effect of Photobiomodulation on Repairing Pressure Ulcers in Adult and Elderly  Patients: A Systematic Review

Pressure ulcers are highly prevalent among adult and elderly patients where risk factors vary. In addition to guidelines to the conventional treatment, some auxiliary therapies such as photobiomodulation have shown promising results in wound healing. In this systematic review, only 5 papers were selected according to the eligibility criteria of this research. It was observed that PBMT red wavelength, similar to standard care, promoted tissue repair with a reduced lesion area. AbstractEvaluation of photobiomodulation therapy (PBMT) in the treatment of pressure ulcers in adults and the elderly. Systematic review, based on the recommendations of the handbook, proposed by Cochrane. The search was carried out in databases, records of randomized clinical trials, list of references cited in the selected articles, as well as a manual search in meetings and specialized journals. A total of 1342 studies were identified, 18 were preselected and 5 were included in this review. Clinical heterogeneity of the participants was observed, in addition to variation in the laser parameters and predominance of studies of low methodological quality. PBMT with the use of laser (658  nm; 4 J cm−2;50  mw) showed complete wound healing (P 
Source: Photochemistry and Photobiology - Category: Science Authors: Tags: Research Article Source Type: research

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AbstractThe aim of this study was to evaluate the effects of photobiomodulation (PBM) by dual-wavelength low-power lasers on the healing and bacterial bioburden of pressure ulcer (PU) models. Twenty-five male Swiss mice were divided into five equal groups. Ischemia reperfusion cycles were employed to cause PU formation by the external application of magnetic plates. Immediately after wounding, a suspension ofPantoea agglomerans was applied at the base of all the wounds of the infected groups, using a calibrated pipette. PBM (simultaneous emission at 660 and 808  nm, 142.8 J/cm2, in continuous wave emission mode) ...
Source: Lasers in Medical Science - Category: Laser Surgery Source Type: research
Abstract In our previous study, we proposed an animal model in which pressure ulcer-like dermal lesions can be produced by denervation of the sciatic nerve and application of a pressure load to rat heel skin. In the present study, we divided these animals into non-treated and pressure loading groups, and initiated hindlimb unloading (depressurization) by tail suspension at 1, 3, 5, 7, and 14 days after inflicting lesions (1-14d pressurization groups). Chronological changes in heel lesions were examined morphologically in all treatment groups after 1, 3, 7, 14, 28, and 40 days. Open dermal lesions were formed by 14...
Source: Acta Histochemica - Category: Biochemistry Authors: Tags: Acta Histochem Source Type: research
AbstractEvaluation of photobiomodulation therapy (PBMT) in the treatment of pressure ulcers in adults and the elderly. Method: Systematic review, based on the recommendations of the Handbook, proposed by Cochrane. The search was carried out in databases, records of randomized clinical trials, list of references cited in the selected articles, as well as a manual search in meetings and specialized journals. Results: 1342 studies were identified, 18 were pre ‐selected and 5 were included in this review. Clinical heterogeneity of the participants was observed, in addition to variation in the laser parameters and predominanc...
Source: Photochemistry and Photobiology - Category: Science Authors: Tags: Research Article Source Type: research
CONCLUSIONS: In these 3 cases, RTM-equipped NPWT and the patient-centric exchanges with the VTS through adherence calls helped promote consistent usage of RTM-equipped NPWT to address the patients' therapeutic needs and increase therapy adherence. PMID: 31483754 [PubMed - in process]
Source: Wounds - Category: General Medicine Tags: Wounds Source Type: research
CONCLUSIONS: Use of NPWT with the microadhesive dressing proved successful in the management of this complex and challenging ECF.
Source: Journal of Wound, Ostomy and Continence Nursing - Category: Nursing Tags: Challenges in Practice Source Type: research
We present a generalized IRI model considering external loading, dynamic tissue healing capacity, accumulating mechanical and reperfusion-mediated damages and competing repair processes of saturating nature. Reperfusion depends on strain and strain rate to enhance loading history sensitivity. Tissue-specific ulceration susceptibility is assumed dependent on variable accumulated damage. We study damage evolution under cyclic loading having several strain expulsion profiles and demonstrate load relief history has critical impact on PU progression. Abrupt load removal generally follows existing models representing extreme rep...
Source: Biomechanics and Modeling in Mechanobiology - Category: Biomedical Science Authors: Tags: Biomech Model Mechanobiol Source Type: research
ConclusionGradual postoperative closure of a traumatic abdominal wall hernia with an ostomy in place may result in stomal stenosis. Stomal patency must be carefully evaluated during this process.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
In conclusion, there is solid evidence that obesity deregulates cellular mechanisms related to nutrient sensing. Altered Intercellular Communication It is accepted that aging impacts the organism at the cellular level, but also decreases the capacity of cells of an organism to interact. During aging, there is a decreased communication at the neuronal, neuroendocrine, and endocrine levels. Two of the most compelling examples of impaired communication are inflammaging and immunosenescence. The inflammaging phenotype results in elevated cytokines. These cytokines can accelerate and propagate the aging process. T...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In this study, exosomes from human embryonic stem cells (ESC-Exos) were locally applied to treat pressure ulcer wounds in an aged mice model induced by D-gal treatment. We found that chronic ESC-Exos treatment effectively rejuvenate endothelial cell senescence and promote angiogenesis, enhancing wound healing. Angiogenesis, the process by which new blood vessels are formed, plays vital roles in wound healing. We have previously reported that the underlying mechanisms of tissue recovery after exosome treatment partly involve exosome-mediated pro-angiogenesis effects, including cutaneous wound healing, ischemic hindli...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
Wound care is a major public health burden, frequently in patients with diabetes, pressure ulcers, prolonged immobilization, and venous insufficiency. To find better wound treatments, we and others have shown the importance of the innate immune response in coordinating the earliest events after wounding. To determine the role of neutrophils in wound healing, we performed full-thickness punch biopsies on mouse back skin and measured neutrophil recruitment by FACS analysis. We find that shortly after wounding, neutrophils are rapidly recruited to the wound site, where they can prevent infection and facilitate repair.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Tissue Regeneration and Wound Healing Source Type: research
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