“Tuft Cells”: A New Player in Hirschsprung's Disease

Conclusion DCLK1 is significantly downregulated in HSCR colon, suggesting a role for tuft cells in cholinergic neurotransmission of the distal colon. The marked decrease in DCLK1 expression within ganglionic specimens highlights the physiologically abnormal nature of this segment in HSCR patients. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: European Journal of Pediatric Surgery - November 9, 2019 Category: Surgery Authors: O'Donnell, Anne Marie Nakamura, Hiroki Puri, Prem Tags: Original Article Source Type: research